Silclog
Generic Name
Clopidogrel
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| silclog 75 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Silclog 75 mg Tablet contains Clopidogrel, an antiplatelet medication used to prevent blood clots in patients with heart disease, recent stroke, or peripheral arterial disease. It works by preventing platelets from clumping together.
Uses & Indications
Dosage
Adults
Standard dose for MI, stroke, PAD: 75 mg once daily. For ACS (loading dose): 300 mg or 600 mg, followed by 75 mg once daily.
Elderly
No specific dose adjustment generally required, but caution is advised.
Renal_impairment
No dose adjustment necessary for mild to moderate renal impairment. Caution in severe impairment.
How to Take
Administer orally, with or without food. Take at the same time each day.
Mechanism of Action
Clopidogrel is a prodrug that is metabolized to its active form. The active metabolite irreversibly binds to the P2Y12 adenosine diphosphate (ADP) receptor on platelets, preventing ADP-mediated platelet activation and aggregation.
Pharmacokinetics
Onset
Platelet inhibition observed within 2 hours, maximal effect within 3-7 days of repeated dosing.
Excretion
Approximately 50% via urine and 46% via feces within 5 days.
Half life
Active metabolite has a short half-life (approx. 30 minutes), but the effect is irreversible. Parent drug has a half-life of 6 hours.
Absorption
Rapidly absorbed after oral administration, but extensively metabolized (first-pass effect). Bioavailability is low.
Metabolism
Primarily hepatic, via cytochrome P450 enzymes (mainly CYP2C19, CYP1A2, CYP2B6).
Side Effects
Contraindications
- Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage).
- Hypersensitivity to clopidogrel or any component of the product.
- Severe hepatic impairment.
Drug Interactions
CYP2C19 Inhibitors
May reduce clopidogrel's effectiveness.
Proton Pump Inhibitors (PPIs) e.g., Omeprazole
May reduce clopidogrel's antiplatelet effect (CYP2C19 inhibition).
Warfarin, NSAIDs, other antiplatelets (e.g., Aspirin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to prolonged bleeding time and subsequent bleeding complications. Management is symptomatic and supportive; platelet transfusion may be considered if bleeding is severe.
Pregnancy & Lactation
Pregnancy: Use only if clearly needed. Animal studies show no direct harmful effects, but human data are limited. Lactation: It is not known whether clopidogrel is excreted in human milk. A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage).
- Hypersensitivity to clopidogrel or any component of the product.
- Severe hepatic impairment.
Drug Interactions
CYP2C19 Inhibitors
May reduce clopidogrel's effectiveness.
Proton Pump Inhibitors (PPIs) e.g., Omeprazole
May reduce clopidogrel's antiplatelet effect (CYP2C19 inhibition).
Warfarin, NSAIDs, other antiplatelets (e.g., Aspirin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to prolonged bleeding time and subsequent bleeding complications. Management is symptomatic and supportive; platelet transfusion may be considered if bleeding is severe.
Pregnancy & Lactation
Pregnancy: Use only if clearly needed. Animal studies show no direct harmful effects, but human data are limited. Lactation: It is not known whether clopidogrel is excreted in human milk. A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., CAPRIE, CURE, COMMIT, CREDO, CLARITY-TIMI 28) have demonstrated clopidogrel's efficacy in preventing atherothrombotic events.
Lab Monitoring
- Monitor for signs of bleeding.
- Complete blood count (CBC) with platelet count periodically.
- Liver function tests if hepatic impairment is present.
Doctor Notes
- Counsel patients on bleeding risks and symptoms.
- Avoid co-administration with strong CYP2C19 inhibitors where possible.
- Discontinue 5-7 days prior to elective surgery if antiplatelet effect is not required.
Patient Guidelines
- Take exactly as prescribed, do not stop without consulting your doctor.
- Report any unusual bleeding or bruising immediately.
- Inform your doctor or dentist you are taking clopidogrel before any surgery or dental procedure.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Clopidogrel has no or negligible influence on the ability to drive and use machines.
Lifestyle Advice
- Avoid activities that may cause injury or bleeding.
- Maintain a healthy lifestyle, including diet and exercise, as advised by your doctor.
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