Silmon
Generic Name
Montelukast
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| silmon 10 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Silmon (Montelukast) is a leukotriene receptor antagonist used for the treatment of asthma and allergic rhinitis, and for the prevention of exercise-induced bronchoconstriction.
Uses & Indications
Dosage
Adults
Adults and adolescents 15 years and older: 10 mg once daily in the evening.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take orally once daily in the evening, with or without food. For asthma, it should be taken in the evening. For allergic rhinitis, the time of administration may be individualized to suit patient needs.
Mechanism of Action
Montelukast selectively antagonizes the CysLT1 receptor, preventing the actions of leukotrienes (LTC4, LTD4, LTE4). These leukotrienes are potent inflammatory mediators that cause bronchoconstriction, mucus secretion, vascular permeability, and eosinophil recruitment, all contributing to asthma and allergic rhinitis symptoms. By blocking these receptors, Montelukast helps to reduce these effects.
Pharmacokinetics
Onset
Clinical improvement in asthma symptoms is generally seen within one day.
Excretion
Primarily excreted in feces via bile (approximately 86%), with less than 0.2% excreted in urine.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations (Cmax) are reached in approximately 2-4 hours for 10 mg tablets.
Metabolism
Extensively metabolized in the liver primarily by CYP3A4 and CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to montelukast or any component of the formulation.
- Acute asthma attacks (not indicated for rapid relief of acute bronchospasm).
Drug Interactions
Rifampicin
May decrease plasma concentrations of montelukast. Clinical monitoring for asthma control is recommended.
Phenobarbital
May decrease the plasma concentration of montelukast. No dosage adjustment is generally recommended.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, the most frequently reported adverse events were abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive. It is not known whether montelukast is dialyzable by peritoneal or hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Montelukast is excreted in human milk, so caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Generic versions available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated montelukast's efficacy and safety in preventing and treating asthma and allergic rhinitis across various age groups.
Lab Monitoring
- No routine laboratory monitoring is required for montelukast. Liver function tests may be considered if symptoms of liver dysfunction occur.
Doctor Notes
- Emphasize that Silmon is a prophylactic agent, not for acute relief.
- Educate patients/caregivers about potential neuropsychiatric symptoms and the need to report them.
- Ensure compliance with once-daily evening dosing for optimal asthma control.
Patient Guidelines
- Take Silmon daily, even if you feel well, as it helps prevent asthma symptoms.
- Silmon is not for use in acute asthma attacks. Use a fast-acting inhaler for sudden asthma symptoms.
- Report any mood or behavior changes to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Patients should be advised that montelukast may cause dizziness or somnolence. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known asthma and allergy triggers (e.g., dust mites, pollen, pet dander).
- Maintain a healthy lifestyle, including regular exercise (if appropriate) and a balanced diet.
- Discuss smoking cessation with your doctor if applicable.
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Global Brand Names
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