Siloflo
Generic Name
Silodosin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| siloflo 4 mg capsule | ৳ 8.00 | ৳ 80.00 |
| siloflo 8 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Silodosin is a selective alpha-1A adrenergic receptor antagonist used for treating the signs and symptoms of benign prostatic hyperplasia (BPH).
Uses & Indications
Dosage
Adults
8 mg once daily with a meal. For renal impairment (CrCl 30-50 mL/min), 4 mg once daily.
Elderly
No specific adjustment needed, but monitor renal function.
Renal_impairment
CrCl 30-50 mL/min: 4 mg once daily. CrCl < 30 mL/min: Contraindicated.
How to Take
Take orally once daily with a meal. Do not crush or chew.
Mechanism of Action
Selectively blocks alpha-1A adrenergic receptors in the prostate, bladder base, and prostatic capsule, leading to relaxation of smooth muscle in these tissues and improving urine flow.
Pharmacokinetics
Onset
Symptomatic improvement within a few days to weeks.
Excretion
Primarily excreted in urine (33.5%) and feces (54.9%).
Half life
Approximately 11-13 hours (parent compound and active metabolite).
Absorption
Rapidly absorbed. Peak plasma concentrations in 1-2 hours. Bioavailability approx. 32%.
Metabolism
Primarily metabolized in the liver (CYP3A4, UGT2B7). Active metabolite KMD-3213.
Side Effects
Contraindications
- Severe renal impairment (CrCl < 30 mL/min)
- Severe hepatic impairment
- Concomitant use with strong CYP3A4 inhibitors
- Hypersensitivity to silodosin
Drug Interactions
Alpha-blockers (e.g., prazosin, doxazosin)
Increased risk of orthostatic hypotension.
Moderate CYP3A4 inhibitors (e.g., diltiazem)
Use with caution.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
Increased risk of orthostatic hypotension.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
Contraindicated due to increased silodosin exposure.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
May cause severe orthostatic hypotension. Supportive treatment, maintain cardiovascular stability.
Pregnancy & Lactation
Not indicated for women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years, check package for specific date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
Clinical Trials
Several clinical trials have demonstrated efficacy and safety in BPH patients.
Lab Monitoring
- Not routinely required.
- Monitor PSA levels for BPH patients.
Doctor Notes
- Counsel patients on orthostatic hypotension risk.
- Assess for concomitant medications, especially CYP3A4 inhibitors and other alpha-blockers.
Patient Guidelines
- Take as directed with food.
- Be cautious when standing up quickly due to potential dizziness.
- Inform doctor if symptoms worsen or new symptoms appear.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it's almost time for the next dose, skip the missed dose and resume the regular schedule. Do not double dose.
Driving Precautions
May cause dizziness; avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Avoid activities that require mental alertness until effects are known.
- Avoid alcohol, which may worsen dizziness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.