Simet
Generic Name
Simethicone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| simet 67 mg pediatric drop | ৳ 30.20 | N/A |
Description
Overview of the medicine
Simet Pediatric Drop contains Simethicone, an antiflatulent agent used to relieve painful symptoms of excess gas in the digestive tract, such as bloating, fullness, and flatulence. It helps break down gas bubbles, making them easier to pass.
Uses & Indications
Dosage
Adults
Not for adult use. For infants (<2 years): 20 mg (approx. 0.3 mL of 67 mg/mL drop) up to 4 times daily after meals and at bedtime. For children (2-12 years): 40 mg (approx. 0.6 mL of 67 mg/mL drop) up to 4 times daily after meals and at bedtime. Or as directed by physician.
Elderly
Not applicable for this pediatric formulation.
Renal_impairment
No dosage adjustment required as Simethicone is not absorbed systemically.
How to Take
Administer orally. Shake the bottle well before each use. Use the calibrated dropper provided to measure the exact dose. Can be given directly or mixed with formula, breast milk, or water. Administer after meals and at bedtime.
Mechanism of Action
Simethicone works by reducing the surface tension of gas bubbles in the gastrointestinal tract, causing them to coalesce into larger bubbles that are more easily passed or absorbed. It does not prevent gas formation but facilitates its elimination.
Pharmacokinetics
Onset
Onset of action is relatively rapid, typically within minutes to an hour.
Excretion
Excreted unchanged in the feces.
Half life
Not applicable, as Simethicone is not absorbed systemically.
Absorption
Simethicone is physiologically inert and is not absorbed from the gastrointestinal tract into the bloodstream.
Metabolism
Not metabolized in the body.
Side Effects
Contraindications
- Known hypersensitivity to Simethicone or any component of the formulation.
- Suspected or known intestinal obstruction or perforation.
Drug Interactions
Thyroid hormones
Simethicone may transiently bind to thyroid hormones, potentially reducing their absorption. Administer thyroid hormones several hours apart from Simethicone.
Storage
Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely to cause systemic toxicity due to the lack of systemic absorption. In case of accidental ingestion of a very large amount, symptomatic and supportive measures may be initiated if necessary.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation as Simethicone is not absorbed systemically. However, always consult a healthcare professional before use.
Side Effects
Contraindications
- Known hypersensitivity to Simethicone or any component of the formulation.
- Suspected or known intestinal obstruction or perforation.
Drug Interactions
Thyroid hormones
Simethicone may transiently bind to thyroid hormones, potentially reducing their absorption. Administer thyroid hormones several hours apart from Simethicone.
Storage
Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely to cause systemic toxicity due to the lack of systemic absorption. In case of accidental ingestion of a very large amount, symptomatic and supportive measures may be initiated if necessary.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation as Simethicone is not absorbed systemically. However, always consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved
Patent Status
Generic
Clinical Trials
Numerous clinical studies have demonstrated the efficacy of Simethicone in reducing gas symptoms and abdominal discomfort. While some studies on infant colic show mixed results, its safety profile for this indication is well-established.
Lab Monitoring
- No specific laboratory monitoring is required for Simethicone therapy.
Doctor Notes
- Emphasize to parents that Simethicone is for symptomatic relief and does not treat the underlying cause of excessive gas.
- Advise parents on proper measurement and administration techniques.
- Counsel on lifestyle modifications like proper feeding techniques and avoiding gas-producing foods (if applicable).
- If symptoms persist or worsen, further medical evaluation is necessary to rule out other conditions.
Patient Guidelines
- Shake the bottle well before each use.
- Use the provided dropper to ensure accurate dosing.
- Do not exceed the recommended dose unless advised by a doctor.
- If symptoms persist or worsen, consult a healthcare professional.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take the next dose as scheduled. Do not take a double dose to compensate for a missed one.
Driving Precautions
Not applicable, as Simethicone is not absorbed and does not cause central nervous system effects or impair the ability to drive or operate machinery.
Lifestyle Advice
- For infants with colic, try comforting techniques like burping, gentle massage, and ensuring proper feeding position. Avoid gas-producing foods in the mother's diet if breastfeeding.
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Global Brand Names
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