Simulect
Generic Name
Basiliximab
Manufacturer
Novartis
Country
Switzerland
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| simulect 20 mg injection | ৳ 102,884.00 | N/A |
Description
Overview of the medicine
Simulect (basiliximab) is a monoclonal antibody used to prevent acute organ rejection in adult and pediatric kidney transplant recipients. It works by blocking the interleukin-2 receptor on activated T-lymphocytes, thereby suppressing the immune response.
Uses & Indications
Dosage
Adults
Total dose of 40 mg, given as two 20 mg doses. First 20 mg dose within 2 hours prior to transplant surgery. Second 20 mg dose 4 days after transplant.
Elderly
No specific dosage adjustment required; use with caution.
Renal_impairment
No dosage adjustment required.
How to Take
For intravenous administration only. Reconstitute with 5 mL of sterile water for injection, then dilute in 50 mL or 100 mL of 0.9% sodium chloride or 5% dextrose solution. Administer by intravenous infusion over 20-30 minutes.
Mechanism of Action
Basiliximab is a chimeric (mouse/human) monoclonal antibody that specifically binds to the alpha-subunit (CD25) of the interleukin-2 (IL-2) receptor on the surface of activated T-lymphocytes. This binding prevents IL-2 from binding to its receptor, thereby blocking IL-2-mediated T-cell activation and proliferation, which are critical steps in the acute immune response to an allograft.
Pharmacokinetics
Onset
Rapid onset; receptor saturation achieved within hours of infusion.
Excretion
Primarily via systemic catabolism, with minimal renal excretion.
Half life
Approximately 7.2 days in adults, 9.4 days in children.
Absorption
Administered intravenously, thus 100% bioavailability.
Metabolism
Not metabolized by cytochrome P450 enzymes. Catabolized into smaller peptides and amino acids like other antibodies.
Side Effects
Contraindications
- Known hypersensitivity to basiliximab or any component of the formulation.
Drug Interactions
Live Vaccines
Avoid live vaccines due to immunosuppression.
Other Immunosuppressants
Used in combination, potential for increased immunosuppression.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Overdose
Limited clinical experience with overdose. Management should be supportive and directed toward alleviation of symptoms.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Unknown if excreted in human milk; exercise caution.
Side Effects
Contraindications
- Known hypersensitivity to basiliximab or any component of the formulation.
Drug Interactions
Live Vaccines
Avoid live vaccines due to immunosuppression.
Other Immunosuppressants
Used in combination, potential for increased immunosuppression.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Overdose
Limited clinical experience with overdose. Management should be supportive and directed toward alleviation of symptoms.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Unknown if excreted in human milk; exercise caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored as recommended. Refer to product label.
Availability
Hospitals, Specialty Pharmacies
Approval Status
Approved
Patent Status
Patent expired for original drug, generic versions may exist
Clinical Trials
Extensive clinical trials (e.g., CHIBP, CHIBP-II) established efficacy in preventing acute renal transplant rejection. Data available from Novartis and regulatory submissions.
Lab Monitoring
- Monitor renal function (creatinine, BUN).
- Monitor blood pressure.
- Monitor for signs of infection.
Doctor Notes
- Administer under the supervision of a physician experienced in immunosuppressive therapy and organ transplantation.
- Closely monitor for signs of infection and hypersensitivity reactions.
Patient Guidelines
- Inform your doctor about all existing medical conditions and medications.
- Report any signs of infection (fever, chills, sore throat) immediately.
- Do not receive live vaccines without consulting your transplant team.
Missed Dose Advice
Simulect is typically given around transplant surgery. If a scheduled dose is missed, contact the transplant team immediately.
Driving Precautions
No specific precautions. May cause headache or dizziness in some patients, if so, caution is advised.
Lifestyle Advice
- Maintain good hygiene to reduce infection risk.
- Avoid large crowds and contact with people who are sick.
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