Sinecod-SR
Generic Name
Butamirate Citrate
Manufacturer
Novartis (Bangladesh) Limited
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinecod sr 50 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Sinecod-SR 50 mg tablet is a sustained-release formulation containing Butamirate Citrate, used as a non-opioid cough suppressant to relieve dry, unproductive coughs. Its sustained-release action provides prolonged relief.
Uses & Indications
Dosage
Adults
One 50 mg SR tablet once or twice daily, as directed by physician. Maximum 100 mg/day.
Elderly
No specific dose adjustment required, but caution is advised in elderly patients with impaired renal or hepatic function.
Renal_impairment
No specific dose adjustment guidelines; use with caution.
How to Take
Swallow the tablet whole with water. Do not chew or crush. Can be taken with or without food.
Mechanism of Action
Butamirate Citrate acts centrally on the cough reflex center in the brainstem, specifically by inhibiting afferent vagal nerve activity, thereby suppressing the cough reflex without affecting the respiratory center.
Pharmacokinetics
Onset
Typically within 30-60 minutes, with sustained effect due to SR formulation.
Excretion
Primarily excreted via the kidneys in the urine, mainly as metabolites.
Half life
Approximately 4-6 hours for the active metabolite, with prolonged effective half-life due to SR formulation.
Absorption
Readily and rapidly absorbed after oral administration, with sustained-release formulation providing prolonged absorption.
Metabolism
Extensively metabolized in the liver to active metabolites, primarily 2-phenylbutyric acid and diethylaminoethoxyethanol.
Side Effects
Contraindications
- Hypersensitivity to Butamirate Citrate or any component of the formulation
- Children under 6 years for SR tablets (or as specified by local guidelines)
Drug Interactions
Other Drugs
No significant clinically relevant drug interactions have been reported.
Expectorants/Mucolytics
Concomitant use with expectorants or mucolytics may lead to accumulation of bronchial secretions due to inhibition of the cough reflex.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, diarrhea, dizziness, and hypotension. Management involves symptomatic and supportive treatment, gastric lavage, and activated charcoal if overdose is recent.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy if the benefits outweigh the risks. Not recommended during the first trimester. Limited data on excretion into breast milk; use with caution in lactating mothers.
Side Effects
Contraindications
- Hypersensitivity to Butamirate Citrate or any component of the formulation
- Children under 6 years for SR tablets (or as specified by local guidelines)
Drug Interactions
Other Drugs
No significant clinically relevant drug interactions have been reported.
Expectorants/Mucolytics
Concomitant use with expectorants or mucolytics may lead to accumulation of bronchial secretions due to inhibition of the cough reflex.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, diarrhea, dizziness, and hypotension. Management involves symptomatic and supportive treatment, gastric lavage, and activated charcoal if overdose is recent.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy if the benefits outweigh the risks. Not recommended during the first trimester. Limited data on excretion into breast milk; use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Butamirate Citrate in various types of cough.
Lab Monitoring
- Generally not required for routine use.
Doctor Notes
- Advise patients that Butamirate is for symptomatic relief of dry cough. Investigate persistent cough.
- Inform about potential for mild gastrointestinal side effects and dizziness.
Patient Guidelines
- Do not exceed the recommended dose.
- Do not use for more than 7 days without consulting a doctor.
- If cough persists or worsens, or if accompanied by fever, rash, or persistent headache, consult a physician.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Drink plenty of fluids to help thin mucus and ease coughing.
- Avoid irritants like smoke and dust.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.