Sinoline
Generic Name
Sinolastine Syrup
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinoline 100 mg syrup | ৳ 85.00 | N/A |
Description
Overview of the medicine
Sinoline 100 mg Syrup contains Sinolastine, a potent second-generation antihistamine with decongestant properties, used for the relief of symptoms associated with allergic rhinitis and common cold.
Uses & Indications
Dosage
Adults
Adults and children 12 years and older: 10 ml (200 mg) once daily.
Elderly
No special dosage adjustment required, but caution in patients with impaired renal or hepatic function.
Renal_impairment
Reduce dose to 5 ml (100 mg) once daily for creatinine clearance <30 ml/min.
How to Take
Oral. May be taken with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Sinolastine acts as a selective peripheral H1-receptor antagonist, inhibiting the effects of histamine. Its decongestant action is due to alpha-adrenergic activity, causing vasoconstriction in nasal passages, reducing swelling and congestion.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted in urine (70%) and feces (30%) as metabolites.
Half life
Approximately 8-12 hours
Absorption
Rapidly absorbed from the GI tract. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily hepatic metabolism via CYP3A4 and CYP2D6 isoenzymes.
Side Effects
Contraindications
- Hypersensitivity to Sinolastine or any component of the syrup
- Severe hypertension
- Severe coronary artery disease
- Patients receiving MAO inhibitor therapy or within 14 days of discontinuing such treatment
Drug Interactions
Beta-blockers
May increase the risk of hypertension and bradycardia.
MAO Inhibitors
May prolong and intensify the cardiac and vasopressor effects of the decongestant component.
Tricyclic Antidepressants
May increase the risk of cardiovascular effects.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, hypertension, and seizures. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, caution advised.
Side Effects
Contraindications
- Hypersensitivity to Sinolastine or any component of the syrup
- Severe hypertension
- Severe coronary artery disease
- Patients receiving MAO inhibitor therapy or within 14 days of discontinuing such treatment
Drug Interactions
Beta-blockers
May increase the risk of hypertension and bradycardia.
MAO Inhibitors
May prolong and intensify the cardiac and vasopressor effects of the decongestant component.
Tricyclic Antidepressants
May increase the risk of cardiovascular effects.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, hypertension, and seizures. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Extensive Phase I, II, and III clinical trials demonstrated efficacy and safety in treating allergic rhinitis and cold symptoms.
Lab Monitoring
- No routine lab monitoring required.
- Monitor blood pressure in hypertensive patients.
Doctor Notes
- Advise patients on proper use of measuring device.
- Caution in patients with glaucoma, prostatic hypertrophy, or thyroid dysfunction.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all current medications.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid known allergens.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.