Sintel
Generic Name
Cefixime
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sintel 200 mg suspension | ৳ 23.00 | N/A |
Description
Overview of the medicine
Cefixime is an oral third-generation cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
200 mg twice daily or 400 mg once daily, for 7 to 14 days depending on the infection.
Elderly
No specific dose adjustment required unless severe renal impairment.
Renal_impairment
Adjust dose based on creatinine clearance (e.g., if CrCl < 60 mL/min, reduce dose).
How to Take
Oral. Can be taken with or without food. Shake suspension well before use.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Within 1 hour
Excretion
Renal excretion (about 50% unchanged in urine), and some biliary excretion.
Half life
Average 3-4 hours
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption.
Metabolism
Not extensively metabolized; primarily eliminated as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- History of anaphylaxis to penicillin
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Probenecid
Increases cefixime plasma levels.
Storage
Store dry powder below 30°C. Reconstituted suspension should be stored at room temperature or refrigerated and used within specific days (check label).
Overdose
Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not effective in removing Cefixime.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during lactation; small amounts may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- History of anaphylaxis to penicillin
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Probenecid
Increases cefixime plasma levels.
Storage
Store dry powder below 30°C. Reconstituted suspension should be stored at room temperature or refrigerated and used within specific days (check label).
Overdose
Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not effective in removing Cefixime.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during lactation; small amounts may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for powder, 7-14 days after reconstitution (stored at room temperature or refrigerated).
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied for efficacy in various bacterial infections, demonstrating broad-spectrum activity.
Lab Monitoring
- Renal function tests (for prolonged therapy or impaired renal function)
- Liver function tests (rarely)
Doctor Notes
- Advise patients on the importance of completing the full course.
- Monitor for signs of C. difficile-associated diarrhea.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve.
- Shake the suspension well before each use.
- Do not store leftover suspension.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's near the time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
Generally not expected to affect ability to drive or operate machinery. However, if dizziness occurs, avoid such activities.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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