Sizonil
Generic Name
Aripiprazole
Manufacturer
Unimed Unihealth Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sizonil 5 mg tablet | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Sizonil 5 mg Tablet contains Aripiprazole, an atypical antipsychotic used to treat mental health conditions like schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 10-15 mg/day, target 10-15 mg/day. Max 30 mg/day. Bipolar Mania: Initial 15 mg/day. Max 30 mg/day.
Elderly
Lower starting doses may be considered, particularly in those with cardiac conditions or a predisposition to orthostatic hypotension. Dose adjustments should be gradual.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Orally, once daily, with or without food. Tablets can be taken whole or dissolved in liquid.
Mechanism of Action
Aripiprazole is thought to work by acting as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors. It modulates dopaminergic and serotonergic activity in the brain.
Pharmacokinetics
Onset
Antipsychotic effects may take several weeks to manifest fully. Initial response can be seen within days to weeks.
Excretion
Mainly excreted via feces (55%) and urine (25%).
Half life
Approximately 75 hours for aripiprazole and 94 hours for its active metabolite dehydro-aripiprazole.
Absorption
Well absorbed orally, peak plasma concentrations typically reached within 3-5 hours.
Metabolism
Extensively metabolized by cytochrome P450 enzymes, primarily CYP2D6 and CYP3A4, to its active metabolite dehydro-aripiprazole.
Side Effects
Contraindications
- Hypersensitivity to Aripiprazole or any component of the formulation
- Concomitant use with strong CYP3A4 or CYP2D6 inhibitors if not properly dose-adjusted
Drug Interactions
CYP3A4 Inducers (e.g., Carbamazepine, Rifampin)
May decrease Aripiprazole levels; dose increase of Aripiprazole may be necessary.
CNS Depressants (e.g., Alcohol, Benzodiazepines)
May potentiate sedative effects.
CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole)
May increase Aripiprazole levels; dose reduction of Aripiprazole may be necessary.
CYP2D6 Inhibitors (e.g., Quinidine, Fluoxetine, Paroxetine)
May increase Aripiprazole levels; dose reduction of Aripiprazole may be necessary.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, vomiting, tremor, and tachycardia. Management involves supportive therapy, maintaining an adequate airway, oxygenation, and ventilation. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to potential for excretion in breast milk and adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous randomized, double-blind, placebo-controlled trials for its approved indications, demonstrating efficacy and safety.
Lab Monitoring
- Blood glucose (periodically)
- Lipid panel (periodically)
- Weight (regularly)
- Blood pressure (regularly)
Doctor Notes
- Closely monitor patients for worsening depression, suicidal thoughts, or unusual changes in behavior, especially during initial therapy or dose changes.
- Educate patients on symptoms of NMS and tardive dyskinesia.
Patient Guidelines
- Take as directed by your doctor, do not stop without consulting.
- Report any unusual side effects immediately.
- Avoid alcohol while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
May cause drowsiness, dizziness, or blurred vision. Avoid driving or operating machinery until you know how this medication affects you.
Lifestyle Advice
- Maintain a healthy diet and exercise routine to manage weight.
- Stay hydrated.
- Engage in stress-reducing activities.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.