Skisia
Generic Name
Miconazole Nitrate 2.5% + Hydrocortisone 2.5% Cream
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| skisia 25 25 cream | ৳ 135.00 | N/A |
Description
Overview of the medicine
Skisia-25-25-cream is a topical antifungal and corticosteroid combination cream used to treat various skin conditions characterized by fungal infections accompanied by inflammation and itching.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area twice daily, in the morning and evening, for 2-4 weeks. Do not use for more than 4 weeks without medical advice.
Elderly
Same as adult dosage. Use with caution due to thinner skin.
Renal_impairment
No specific dosage adjustment required for topical application.
How to Take
For external use only. Wash and dry the affected area thoroughly before application. Apply a thin layer and gently rub in until absorbed. Avoid contact with eyes and mucous membranes.
Mechanism of Action
Miconazole nitrate inhibits ergosterol synthesis, a vital component of fungal cell membranes, leading to increased permeability and cell death. Hydrocortisone is a corticosteroid that reduces inflammation, itching, and redness by suppressing the immune response.
Pharmacokinetics
Onset
Relief from itching and inflammation often within a few days; complete resolution of fungal infection may take weeks.
Excretion
Excreted via urine and feces if significant systemic absorption occurs.
Half life
Systemic half-life not clinically relevant for topical use. Local tissue half-life varies.
Absorption
Minimal systemic absorption through intact skin. Absorption increases with inflammation, skin damage, or occlusive dressings.
Metabolism
Systemically absorbed components are metabolized by the liver (hydrocortisone, miconazole) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to miconazole, hydrocortisone, or any component of the cream.
- Viral infections of the skin (e.g., herpes simplex, varicella).
- Tuberculosis of the skin.
- Perioral dermatitis, acne, rosacea.
Drug Interactions
Warfarin (oral anticoagulants)
Very rarely, high systemic absorption of miconazole from topical preparations has been reported to potentiate the effect of warfarin, increasing bleeding risk. Monitor INR if used extensively.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Overdose from topical application is unlikely. Excessive use of corticosteroids can lead to local side effects (skin atrophy) or, rarely, systemic effects (Cushing's syndrome, adrenal suppression).
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit outweighs the potential risk. Avoid application to large areas or for prolonged periods. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to miconazole, hydrocortisone, or any component of the cream.
- Viral infections of the skin (e.g., herpes simplex, varicella).
- Tuberculosis of the skin.
- Perioral dermatitis, acne, rosacea.
Drug Interactions
Warfarin (oral anticoagulants)
Very rarely, high systemic absorption of miconazole from topical preparations has been reported to potentiate the effect of warfarin, increasing bleeding risk. Monitor INR if used extensively.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Overdose from topical application is unlikely. Excessive use of corticosteroids can lead to local side effects (skin atrophy) or, rarely, systemic effects (Cushing's syndrome, adrenal suppression).
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit outweighs the potential risk. Avoid application to large areas or for prolonged periods. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic
Clinical Trials
Data available from trials supporting the efficacy and safety of miconazole and hydrocortisone combination products for topical dermatological conditions.
Lab Monitoring
- No routine lab monitoring required for typical topical use.
Doctor Notes
- Advise patients on proper application technique and hygiene.
- Monitor for signs of skin atrophy or lack of improvement, which may indicate inappropriate use or resistant infection.
Patient Guidelines
- Use only as directed by a healthcare professional.
- Complete the full course of treatment, even if symptoms improve.
- Do not use for longer than recommended to avoid side effects, especially with the corticosteroid component.
- Avoid contact with eyes, mouth, and other mucous membranes.
Missed Dose Advice
Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of fungal infections.
- Wear loose-fitting, breathable clothing if applicable.
- Keep affected areas dry.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.