Slipam
Generic Name
Slipam
Manufacturer
MediLife Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| slipam 30 mg capsule | ৳ 9.00 | ৳ 54.00 |
Description
Overview of the medicine
Slipam 30 mg capsule is a benzodiazepine derivative used to treat anxiety disorders, insomnia, and certain other conditions by exerting its anxiolytic, hypnotic, sedative, muscle relaxant, and anticonvulsant effects on the central nervous system.
Uses & Indications
Dosage
Adults
Anxiety: 15-30 mg daily in divided doses or as a single dose at bedtime. Insomnia: 15-30 mg taken at bedtime. Dosage should be individualized.
Elderly
Lower initial doses are recommended, typically 7.5-15 mg daily, to minimize the risk of oversedation and ataxia. Carefully titrate upwards if necessary.
Renal_impairment
Use with caution; dose reduction may be necessary due to potential for accumulation. Monitor closely for adverse effects.
How to Take
Take the capsule orally with a glass of water, with or without food. For insomnia, take it just before bedtime. Do not chew or crush the capsule.
Mechanism of Action
Slipam enhances the effect of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system. It binds to specific benzodiazepine receptors on the GABA-A receptor complex, leading to an increase in chloride ion influx and hyperpolarization of the neuron, which results in decreased neuronal excitability.
Pharmacokinetics
Onset
Anxiolytic/sedative effects typically begin within 30-60 minutes.
Excretion
Excreted primarily in the urine as glucuronide conjugates of the parent drug and its metabolites.
Half life
Parent drug: approximately 20-30 hours; Active metabolites: up to 50-100 hours (for some).
Absorption
Rapidly and well-absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are typically reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes (e.g., CYP3A4, CYP2C19) to active and inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Slipam or other benzodiazepines.
- Severe respiratory insufficiency or acute pulmonary insufficiency.
- Sleep apnea syndrome.
- Severe hepatic insufficiency.
- Myasthenia gravis.
Drug Interactions
Antacids
May delay absorption of Slipam, but usually not clinically significant.
CYP3A4 Inhibitors
Drugs that inhibit CYP3A4 (e.g., ketoconazole, fluvoxamine, grapefruit juice) can increase Slipam plasma levels, leading to enhanced effects and increased risk of adverse reactions.
Central Nervous System (CNS) Depressants
Increased sedative effects when co-administered with alcohol, opioids, barbiturates, antidepressants, antihistamines, and other CNS depressants.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms: Drowsiness, confusion, lethargy, ataxia, dysarthria, and diminished reflexes. In severe cases, hypotension, respiratory depression, coma, and rarely death. Management: Supportive care, including maintaining a clear airway and monitoring vital signs. Flumazenil, a benzodiazepine receptor antagonist, may be used in hospitalized patients for reversal of effects, but should be used with caution due to risk of withdrawal seizures.
Pregnancy & Lactation
Pregnancy: Avoid during pregnancy, especially during the first trimester, due to potential risk of congenital malformations. Use in late pregnancy or during labor may result in neonatal depression (e.g., hypotonia, lethargy, hypothermia). Lactation: Excreted in breast milk and may cause sedation, poor feeding, and weight loss in infants. Avoid during breastfeeding.
Side Effects
Contraindications
- Known hypersensitivity to Slipam or other benzodiazepines.
- Severe respiratory insufficiency or acute pulmonary insufficiency.
- Sleep apnea syndrome.
- Severe hepatic insufficiency.
- Myasthenia gravis.
Drug Interactions
Antacids
May delay absorption of Slipam, but usually not clinically significant.
CYP3A4 Inhibitors
Drugs that inhibit CYP3A4 (e.g., ketoconazole, fluvoxamine, grapefruit juice) can increase Slipam plasma levels, leading to enhanced effects and increased risk of adverse reactions.
Central Nervous System (CNS) Depressants
Increased sedative effects when co-administered with alcohol, opioids, barbiturates, antidepressants, antihistamines, and other CNS depressants.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms: Drowsiness, confusion, lethargy, ataxia, dysarthria, and diminished reflexes. In severe cases, hypotension, respiratory depression, coma, and rarely death. Management: Supportive care, including maintaining a clear airway and monitoring vital signs. Flumazenil, a benzodiazepine receptor antagonist, may be used in hospitalized patients for reversal of effects, but should be used with caution due to risk of withdrawal seizures.
Pregnancy & Lactation
Pregnancy: Avoid during pregnancy, especially during the first trimester, due to potential risk of congenital malformations. Use in late pregnancy or during labor may result in neonatal depression (e.g., hypotonia, lethargy, hypothermia). Lactation: Excreted in breast milk and may cause sedation, poor feeding, and weight loss in infants. Avoid during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
Clinical Trials
Completed Phase III clinical trials demonstrated efficacy and safety in adult patients for generalized anxiety disorder and short-term insomnia.
Lab Monitoring
- Liver function tests (LFTs) should be periodically monitored during prolonged therapy.
- Complete blood count (CBC) may be considered in patients on long-term treatment.
Doctor Notes
- Assess for comorbid psychiatric conditions and substance abuse history before initiating Slipam.
- Counsel patients on the risks of dependence and withdrawal, emphasizing the importance of gradual tapering.
- Monitor elderly patients closely for sedation and falls, initiating with the lowest effective dose.
- Avoid concomitant use with opioids due to severe respiratory depression risk.
Patient Guidelines
- Do not stop taking Slipam suddenly, especially after prolonged use, as this can lead to withdrawal symptoms. Consult your doctor for gradual dose reduction.
- Avoid alcohol and other CNS depressants while taking this medicine.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Slipam can cause drowsiness, dizziness, and impaired coordination, which may affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you.
Lifestyle Advice
- Practice good sleep hygiene (e.g., regular sleep schedule, dark quiet room) to help manage insomnia.
- Engage in stress-reduction techniques such as meditation or yoga to help manage anxiety.
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