Administer by deep intramuscular injection into the gluteal muscle (upper outer quadrant). Not for intravenous (IV) administration unless specifically formulated and indicated. Ensure aseptic technique.

Diclofenac Sodium inhibits prostaglandin synthesis by blocking both cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) enzymes. Prostaglandins are mediators of inflammation, pain, and fever, so their inhibition leads to the therapeutic effects.

• •Hypersensitivity to diclofenac, aspirin, or other NSAIDs
• •Active gastrointestinal bleeding, ulceration, or perforation
• •Severe heart failure (NYHA class II-IV)
• •Third trimester of pregnancy
• •Coronary Artery Bypass Graft (CABG) surgery peri-operative pain
• •Severe hepatic or renal impairment

Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.

Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Gastrointestinal bleeding can occur. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is symptomatic and supportive. Gastric decontamination may be considered if recent oral ingestion.

Pregnancy Category C (first and second trimester), Category D (third trimester). Avoid in the third trimester due to potential risk of premature closure of the fetal ductus arteriosus. Use with caution in first and second trimesters only if potential benefits outweigh risks. Diclofenac is excreted in breast milk; therefore, it is not recommended during lactation.