Sofa
Generic Name
sofa-125-mg-suspension
Manufacturer
Alpha Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sofa 125 mg suspension | ৳ 60.00 | N/A |
Description
Overview of the medicine
Sofa 125 mg Suspension is a broad-spectrum antibiotic indicated for the treatment of various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not typically prescribed for adults in this specific formulation (125 mg suspension). Adult doses are usually higher and in different forms.
Elderly
Use with caution. Dosage adjustment may be necessary for elderly patients with impaired renal function. Consult a physician.
Renal_impairment
Dose modification is required for patients with significant renal impairment. Refer to specific guidelines based on creatinine clearance.
How to Take
Administer orally, preferably with food to minimize gastrointestinal upset. Shake the bottle well before each use. Use the provided measuring spoon or cup for accurate dosing.
Mechanism of Action
Sofa inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial lysis and death.
Pharmacokinetics
Onset
Clinical effects typically observed within 30-60 minutes after the first dose.
Excretion
Mainly via renal excretion (glomerular filtration and tubular secretion) into urine.
Half life
Approximately 1.5-2 hours in healthy individuals, slightly prolonged in renal impairment.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours after oral administration.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- •Known hypersensitivity to Sofa or any other cephalosporin antibiotics.
- •History of severe allergic reactions to penicillin antibiotics.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
Probenecid
Decreases the renal tubular secretion of Sofa, leading to increased and prolonged plasma concentrations.
Aminoglycosides
Concurrent use may increase the risk of nephrotoxicity.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C). Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and in severe cases, neurotoxicity (e.g., convulsions). Management is primarily supportive; gastric lavage or activated charcoal may be considered. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Should be used during pregnancy only if clearly needed. Sofa is excreted in small amounts in breast milk; generally considered compatible with breastfeeding, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months for the unreconstituted powder. 7 to 14 days after reconstitution when stored in a refrigerator (2-8°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent Protected
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