Sonib
Generic Name
Sonib Hydrochloride
Manufacturer
Global Pharma Inc.
Country
USA
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sonib 200 mg tablet | ৳ 120.00 | ৳ 840.00 |
Description
Overview of the medicine
Sonib 200 mg Tablet is a targeted therapy used in the treatment of certain types of cancer. It works by inhibiting specific tyrosine kinases that are involved in cancer cell growth and proliferation.
Uses & Indications
Dosage
Adults
Initial dose 400 mg orally once daily, may be increased to 600 mg or 800 mg daily depending on response and tolerability.
Elderly
No specific dose adjustment recommended, but monitor for increased sensitivity.
Renal_impairment
Mild to moderate renal impairment: No dose adjustment. Severe renal impairment: Consider dose reduction by 25% with close monitoring.
How to Take
Take orally with a meal and a large glass of water to reduce gastrointestinal irritation. Do not crush, cut, or chew the tablet.
Mechanism of Action
Sonib selectively inhibits the activity of certain oncogenic tyrosine kinases, such as BCR-ABL, KIT, and PDGFR. This inhibition blocks downstream signaling pathways crucial for cell proliferation and survival in cancer cells, leading to apoptosis and tumor regression.
Pharmacokinetics
Onset
Clinical effects may be observed within weeks of treatment initiation.
Excretion
Mainly excreted via feces (approximately 80%), with a minor portion eliminated in urine (approximately 15%).
Half life
Approximately 12-18 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 2-4 hours. Bioavailability is approximately 60-70%.
Metabolism
Primarily metabolized in the liver by CYP3A4, with some active metabolites.
Side Effects
Contraindications
- Hypersensitivity to Sonib or any excipients
- Severe liver impairment
Drug Interactions
Strong CYP3A4 inducers (e.g., Rifampicin, Phenytoin)
May decrease Sonib plasma concentrations, reducing efficacy; avoid co-administration.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Sonib plasma concentrations, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include myelosuppression, gastrointestinal disturbances, and severe fluid retention. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category D. May cause fetal harm. Avoid during pregnancy. Advise women of childbearing potential to use effective contraception. Not recommended during breastfeeding as it may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Sonib or any excipients
- Severe liver impairment
Drug Interactions
Strong CYP3A4 inducers (e.g., Rifampicin, Phenytoin)
May decrease Sonib plasma concentrations, reducing efficacy; avoid co-administration.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Sonib plasma concentrations, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include myelosuppression, gastrointestinal disturbances, and severe fluid retention. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category D. May cause fetal harm. Avoid during pregnancy. Advise women of childbearing potential to use effective contraception. Not recommended during breastfeeding as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent protected (brand formulation)
Clinical Trials
Extensive phase I, II, and III clinical trials have demonstrated Sonib's efficacy and safety in indicated cancer types.
Lab Monitoring
- Complete Blood Count (CBC) with differential (weekly for first month, then monthly)
- Liver function tests (LFTs) (baseline, then monthly)
- Renal function tests (baseline, then periodically)
- Electrolytes (periodically)
Doctor Notes
- Emphasize strict adherence to dosing schedule.
- Monitor patients for fluid retention and cardiac function regularly.
- Educate patients on potential drug interactions.
Patient Guidelines
- Take the medicine at the same time each day.
- Report any unusual bleeding, bruising, or signs of infection immediately.
- Do not stop taking the medicine without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or blurred vision. Avoid driving or operating heavy machinery if you experience these symptoms.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol consumption during treatment.
- Follow a balanced diet and regular exercise as advised by your doctor.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.