Sono
Generic Name
Prednisolone
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sono 1 mg tablet | ৳ 1.81 | N/A |
Description
Overview of the medicine
Sono 1 mg tablet contains Prednisolone, a corticosteroid used for its potent anti-inflammatory and immunosuppressive effects. It is used to treat a wide range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Initial dose 5-60 mg daily, adjusted according to response and nature of the disease. For 1 mg tablets, dosage would be tailored to condition.
Elderly
Lower doses may be considered due to increased susceptibility to side effects. Start at the lower end of the adult dosage range.
Renal_impairment
No specific dose adjustment typically required, but monitor for fluid retention.
How to Take
Take orally, preferably with food or milk to minimize gastric irritation. Do not crush or chew the tablet. For once daily dosing, take in the morning.
Mechanism of Action
Prednisolone works by reducing inflammation and suppressing the immune system. It binds to intracellular glucocorticoid receptors, modulating gene expression to produce anti-inflammatory proteins and inhibit the synthesis of pro-inflammatory mediators such as prostaglandins and leukotrienes.
Pharmacokinetics
Onset
Within 1-2 hours for anti-inflammatory effects.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Biological half-life is 18-36 hours, plasma half-life is 2-4 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any component of the formulation
- Live vaccines administration (while on immunosuppressive doses)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Antidiabetics
May increase blood glucose levels, requiring dose adjustment of antidiabetics.
Diuretics (Thiazide/Loop)
Increased risk of hypokalemia.
Anticoagulants (e.g., Warfarin)
May enhance or decrease anticoagulant effects; monitor INR.
Phenytoin, Rifampicin, Barbiturates
May decrease prednisolone effects by increasing its metabolism.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of acute overdose are rare. Chronic overdose can lead to Cushingoid features, muscle weakness, and psychiatric disturbances. Treatment is supportive and symptomatic; gradually reduce the dose under medical supervision.
Pregnancy & Lactation
Pregnancy Category C/D (depending on dosage and duration). Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised. Consult your doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any component of the formulation
- Live vaccines administration (while on immunosuppressive doses)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Antidiabetics
May increase blood glucose levels, requiring dose adjustment of antidiabetics.
Diuretics (Thiazide/Loop)
Increased risk of hypokalemia.
Anticoagulants (e.g., Warfarin)
May enhance or decrease anticoagulant effects; monitor INR.
Phenytoin, Rifampicin, Barbiturates
May decrease prednisolone effects by increasing its metabolism.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of acute overdose are rare. Chronic overdose can lead to Cushingoid features, muscle weakness, and psychiatric disturbances. Treatment is supportive and symptomatic; gradually reduce the dose under medical supervision.
Pregnancy & Lactation
Pregnancy Category C/D (depending on dosage and duration). Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA (Bangladesh) / FDA (USA)
Patent Status
Patent expired, generic available
WHO Essential Medicine
YesClinical Trials
Prednisolone is a well-established generic drug with numerous clinical trials validating its efficacy and safety for various indications. Ongoing research explores new delivery methods and specific indications.
Lab Monitoring
- Blood glucose levels (especially in diabetics)
- Electrolytes (e.g., potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Adrenal function tests (after withdrawal)
Doctor Notes
- Always consider the lowest effective dose for the shortest possible duration.
- Gradual tapering is crucial to prevent adrenal crisis upon discontinuation.
- Monitor patients for signs of infection, fluid retention, blood pressure changes, and bone density loss.
- Educate patients on potential side effects and the importance of adherence and follow-up.
Patient Guidelines
- Do not stop taking this medicine abruptly, especially after long-term use, as it may lead to withdrawal symptoms.
- Always take with food or milk to minimize stomach upset.
- Report any unusual side effects or worsening of symptoms to your doctor.
- Avoid close contact with people who have infections, as your immune system may be suppressed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose.
Driving Precautions
Prednisolone may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet, potentially with calcium and vitamin D supplements for long-term use.
- Engage in regular, moderate exercise to maintain bone and muscle strength.
- Avoid excessive alcohol consumption and smoking.
- Regularly monitor blood sugar if diabetic.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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