Span
Generic Name
Pantoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| span 40 mg tablet | ৳ 1.76 | ৳ 35.20 |
Description
Overview of the medicine
Pantoprazole is a proton pump inhibitor (PPI) used to treat conditions where there is too much acid in the stomach. It works by decreasing the amount of acid the stomach makes.
Uses & Indications
Dosage
Adults
Usually 40 mg once daily, taken before breakfast. For severe conditions, dosage may be increased to 80 mg daily. For H. pylori eradication, 40 mg twice daily in combination with antibiotics.
Elderly
No specific dose adjustment required, but caution is advised in cases of severe hepatic impairment.
Renal_impairment
No dose adjustment necessary.
How to Take
Take the tablet whole with a glass of water, preferably 30-60 minutes before breakfast. Do not chew, crush, or break the tablet.
Mechanism of Action
Pantoprazole irreversibly binds to the H+/K+-ATPase enzyme (the proton pump) on the secretory surface of the parietal cells in the stomach, thereby inhibiting the final step in gastric acid production.
Pharmacokinetics
Onset
Acid secretion inhibition occurs within 2.5 hours, full effect within 2-3 days of continuous therapy.
Excretion
Mainly excreted renally (approximately 71%) and a smaller portion via biliary excretion (approximately 18%) as metabolites.
Half life
Approximately 1 hour (terminal half-life), but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration, bioavailability is approximately 77%. Peak plasma concentrations achieved within 2.5 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation
- Hypersensitivity to other substituted benzimidazoles
Drug Interactions
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.
Atazanavir, Nelfinavir
Reduced absorption due to increased gastric pH.
Ketoconazole, Itraconazole
Reduced absorption of pH-dependent drugs.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Treatment is symptomatic and supportive. Pantoprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies globally (e.g., FDA, EMA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Pantoprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in various acid-related disorders.
Lab Monitoring
- Monitor magnesium levels, especially in patients on long-term therapy or concomitant digoxin/diuretics.
- Consider Vitamin B12 levels for long-term use (more than 3 years).
Doctor Notes
- Consider lowest effective dose and shortest duration of therapy for long-term PPI use.
- Assess for potential drug interactions, especially with clopidogrel and antiretrovirals.
- Monitor for hypomagnesemia in patients at risk.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy foods, caffeine, alcohol, and fatty foods that can worsen acid reflux.
- Maintain a healthy weight and elevate the head of your bed to reduce GERD symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.