Spectazole
Generic Name
Econazole Nitrate
Manufacturer
Ortho-McNeil Pharmaceutical
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| spectazole 1 cream | ৳ 35.00 | N/A |
Description
Overview of the medicine
Spectazole 1% cream is a topical antifungal medication used to treat various skin infections caused by fungi, including athlete's foot, jock itch, ringworm, and other fungal skin infections.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area once daily. Continue treatment for 2-4 weeks, or as directed by a healthcare professional. For pityriasis versicolor, treatment duration is usually 2 weeks.
Elderly
No specific dosage adjustment is generally required for elderly patients; use as for adults.
Renal_impairment
No dosage adjustment needed as systemic absorption is minimal.
How to Take
For external topical use only. Clean and dry the affected area thoroughly before applying the cream. Gently rub a thin layer of cream into the affected skin and surrounding area.
Mechanism of Action
Econazole nitrate works by inhibiting the biosynthesis of ergosterol, an essential component of the fungal cell membrane. This leads to increased permeability of the fungal cell membrane, resulting in leakage of cellular contents and ultimately cell death.
Pharmacokinetics
Onset
Clinical improvement typically seen within a few days of starting treatment, with full resolution taking weeks.
Excretion
Excretion of metabolites primarily occurs via urine and feces.
Half life
Systemic half-life is not clinically relevant for topical administration due to minimal absorption.
Absorption
Minimal systemic absorption (less than 10%) occurs through intact skin after topical application. Absorption increases with inflammation or damaged skin.
Metabolism
Absorbed econazole is metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to econazole nitrate or any other imidazole antifungal agent.
- •Known allergy to any component of the cream.
Drug Interactions
Warfarin
Although systemic absorption is minimal, use with caution in patients taking oral anticoagulants like warfarin, as some imidazole antifungals can potentiate their effect.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children. Protect from light and moisture.
Overdose
Overdose is unlikely with topical application. If accidentally ingested, seek medical advice immediately.
Pregnancy & Lactation
Use during pregnancy or lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant, and under the strict guidance of a healthcare professional. Minimal systemic absorption suggests low risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Expired
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Global Brand Names
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