Spilac-F
Generic Name
Famotidine
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| spilac f 40 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Spilac-F 40 mg Tablet contains Famotidine, an H2-receptor antagonist used to reduce stomach acid production. It is prescribed for the treatment of peptic ulcers, gastroesophageal reflux disease (GERD), and other conditions where excessive stomach acid is a concern.
Uses & Indications
Dosage
Adults
Duodenal/Gastric Ulcer: 40 mg orally once daily at bedtime for 4-8 weeks, or 20 mg twice daily. GERD: 20-40 mg twice daily for 6-12 weeks. Zollinger-Ellison Syndrome: Initial 20 mg every 6 hours; may be increased up to 160 mg every 6 hours.
Elderly
No specific dosage adjustment needed for elderly unless renal impairment is present. Start with lower dose if needed.
Renal_impairment
Creatinine clearance < 10 mL/min: Reduce dose by 50% or extend dosing interval to 36-48 hours.
How to Take
Take orally with or without food. For duodenal ulcer, gastric ulcer, and GERD, it is often taken once daily at bedtime or twice daily. For Zollinger-Ellison Syndrome, it is usually taken multiple times a day.
Mechanism of Action
Famotidine selectively blocks histamine H2-receptors located on the parietal cells of the stomach. This blockade inhibits histamine-stimulated gastric acid secretion, as well as acid secretion stimulated by gastrin and acetylcholine, leading to a reduction in both gastric acid volume and concentration.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted unchanged in the urine (65-70% of absorbed dose). Renal clearance is approximately 250-450 mL/min.
Half life
2.5-3.5 hours (can be prolonged in renal impairment)
Absorption
Rapidly but incompletely absorbed from the gastrointestinal tract; bioavailability is approximately 40-45%. Peak plasma concentrations are achieved within 1-3 hours.
Metabolism
Undergoes minimal hepatic metabolism (25-30%), primarily to an inactive S-oxide metabolite.
Side Effects
Contraindications
- Hypersensitivity to famotidine or other H2-receptor antagonists
- Children under 1 month of age (safety and efficacy not established)
Drug Interactions
Antacids
May decrease absorption of famotidine. Separate administration by 1-2 hours.
Cefpodoxime
Famotidine may decrease Cefpodoxime absorption.
Ketoconazole, Itraconazole
Famotidine may reduce absorption of these drugs due to increased gastric pH. Administer several hours apart.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, abdominal pain, and hypotension. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis is not effective in removing famotidine.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Lactation: Famotidine is excreted in breast milk. Caution should be exercised when administered to a nursing woman. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to famotidine or other H2-receptor antagonists
- Children under 1 month of age (safety and efficacy not established)
Drug Interactions
Antacids
May decrease absorption of famotidine. Separate administration by 1-2 hours.
Cefpodoxime
Famotidine may decrease Cefpodoxime absorption.
Ketoconazole, Itraconazole
Famotidine may reduce absorption of these drugs due to increased gastric pH. Administer several hours apart.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, abdominal pain, and hypotension. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis is not effective in removing famotidine.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Lactation: Famotidine is excreted in breast milk. Caution should be exercised when administered to a nursing woman. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Famotidine has undergone extensive clinical trials demonstrating its efficacy and safety in acid-related disorders. Post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Routine monitoring is generally not required for short-term use.
- Liver function tests (LFTs) and kidney function tests (KFTs) may be considered in prolonged use or in patients with pre-existing hepatic/renal impairment.
Doctor Notes
- Counsel patients on lifestyle modifications (diet, smoking, alcohol) to complement drug therapy.
- Be mindful of renal function; dose adjustment may be necessary in patients with severe impairment.
- Consider potential for masking symptoms of gastric malignancy.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- Inform your doctor if your symptoms do not improve or worsen.
- Avoid alcohol and smoking as they can worsen acid reflux.
- Avoid spicy and fatty foods if they trigger your symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Famotidine may cause dizziness or drowsiness in some individuals. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Raise the head of your bed if you experience nocturnal reflux.
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Global Brand Names
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