sq-mycetin
Generic Name
Chloramphenicol 0.5%
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sq mycetin 05 eye drop | ৳ 34.50 | N/A |
Description
Overview of the medicine
Sq-mycetin 0.5% Eye Drop contains Chloramphenicol, a broad-spectrum antibiotic used to treat bacterial infections of the eye, such as bacterial conjunctivitis, keratitis, and other superficial ocular infections caused by susceptible organisms.
Uses & Indications
Dosage
Adults
Instill 1-2 drops into the affected eye(s) every 2-4 hours initially, reducing frequency as the infection subsides. Treatment usually continues for 5-7 days or as directed by a physician.
Elderly
No specific dosage adjustment required for elderly patients.
Renal_impairment
No dosage adjustment necessary for topical ophthalmic use.
How to Take
Wash hands thoroughly before and after use. Tilt head back, pull down the lower eyelid to form a pouch, and instill the prescribed number of drops into the conjunctival sac. Close the eye gently for a few moments. Avoid touching the dropper tip to the eye or any other surface.
Mechanism of Action
Chloramphenicol acts as a bacteriostatic agent by inhibiting bacterial protein synthesis. It binds reversibly to the 50S ribosomal subunit of susceptible bacteria, preventing peptide bond formation and subsequent protein elongation.
Pharmacokinetics
Onset
Clinical improvement typically seen within 2-3 days of starting treatment.
Excretion
Systemically absorbed metabolites are excreted mainly by the kidneys.
Half life
Not well-defined for topical ophthalmic use; systemic half-life is 1.5-5 hours.
Absorption
Minimal systemic absorption occurs after topical ophthalmic administration. Adequate concentrations are achieved in ocular tissues.
Metabolism
Systemically absorbed Chloramphenicol is primarily metabolized in the liver (glucuronidation).
Side Effects
Contraindications
- Known hypersensitivity to Chloramphenicol or any excipients of the formulation.
- History of bone marrow depression or blood dyscrasias.
Drug Interactions
Other eye drops
If using other ophthalmic medications, wait at least 5 minutes between applications to prevent washout.
Systemic Chloramphenicol
Topical use is generally safe, but theoretically, systemic absorption could interact with drugs like warfarin or phenytoin, though highly unlikely with ophthalmic use.
Storage
Store below 25°C, protected from light. Do not freeze. Keep out of the reach of children.
Overdose
Overdose with topical ophthalmic Chloramphenicol is unlikely due to the small quantity administered. If accidentally ingested, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit outweighs the potential risk. Consult a physician before use. Minimal systemic absorption suggests low risk for topical use.
Side Effects
Contraindications
- Known hypersensitivity to Chloramphenicol or any excipients of the formulation.
- History of bone marrow depression or blood dyscrasias.
Drug Interactions
Other eye drops
If using other ophthalmic medications, wait at least 5 minutes between applications to prevent washout.
Systemic Chloramphenicol
Topical use is generally safe, but theoretically, systemic absorption could interact with drugs like warfarin or phenytoin, though highly unlikely with ophthalmic use.
Storage
Store below 25°C, protected from light. Do not freeze. Keep out of the reach of children.
Overdose
Overdose with topical ophthalmic Chloramphenicol is unlikely due to the small quantity administered. If accidentally ingested, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit outweighs the potential risk. Consult a physician before use. Minimal systemic absorption suggests low risk for topical use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years (unopened). Discard 28 days after first opening.
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by regulatory authorities for ophthalmic use
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Chloramphenicol has been extensively studied for its efficacy in treating various bacterial infections, including ocular infections. Numerous clinical trials and widespread clinical use over decades support its effectiveness for susceptible organisms.
Lab Monitoring
- Not routinely required for topical ophthalmic Chloramphenicol.
Doctor Notes
- Confirm bacterial etiology before prescribing to avoid inappropriate antibiotic use.
- Advise patients on proper administration technique to minimize contamination and ensure efficacy.
- Monitor for signs of superinfection or allergic reactions.
- Emphasize the importance of completing the full course of treatment.
Patient Guidelines
- Use only as directed by your doctor.
- Do not touch the dropper tip to your eye or any other surface to avoid contamination.
- Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them.
- Complete the full course of treatment even if symptoms improve.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
This medicine may cause temporary blurred vision immediately after application. If affected, do not drive or operate machinery until your vision clears.
Lifestyle Advice
- Avoid wearing contact lenses during the treatment period to prevent further irritation and potential infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.