Stanoplex
Generic Name
Desloratadine 5 mg/5 ml syrup
Manufacturer
PharmaCo Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| stanoplex 5 mg syrup | ৳ 35.00 | N/A |
Description
Overview of the medicine
Stanoplex is an antihistamine syrup containing Desloratadine, used to relieve symptoms associated with seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria. It effectively reduces sneezing, runny nose, itchy eyes, nasal congestion, and hives.
Uses & Indications
Dosage
Adults
5 mg (10 ml) once daily, with or without food.
Elderly
No dosage adjustment is generally required in elderly patients with normal renal function. However, caution is advised with renal or hepatic impairment.
Renal_impairment
For patients with severe renal impairment (creatinine clearance <30 mL/min), a dose of 5 mg (10 ml) every other day is recommended.
How to Take
For oral administration. The syrup can be taken with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Desloratadine is a potent, long-acting, selective peripheral H1-receptor antagonist. It inhibits the release of histamine and other mediators from mast cells and basophils, thereby suppressing the effects of histamine in allergic reactions.
Pharmacokinetics
Onset
Symptom relief typically begins within 1 hour after administration.
Excretion
Excreted almost equally via urine (41%) and feces (47%) as metabolites over a 10-day period.
Half life
The elimination half-life of desloratadine is approximately 27 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations (Cmax) are reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8 and CYP3A4, followed by glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to desloratadine, loratadine, or any component of the syrup.
- •Patients with severe hepatic impairment should be monitored closely.
Drug Interactions
Fluoxetine
Minor increases in desloratadine plasma concentrations observed, not considered clinically relevant.
Erythromycin
Similar to ketoconazole, erythromycin can increase desloratadine levels. Clinical significance is generally low.
Ketoconazole
Concomitant administration with ketoconazole may increase desloratadine plasma concentrations, but without clinically significant electrocardiographic changes.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, adverse events reported include drowsiness, tachycardia, and headache. In the event of overdose, symptomatic and supportive treatment should be initiated immediately.
Pregnancy & Lactation
Limited data are available on the use of desloratadine in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, its use is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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