stebet-cl
Generic Name
Clobetasol Propionate 0.05% + Clotrimazole 1% Cream
Manufacturer
General Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| stebet cl 005 1 cream | ৳ 35.00 | N/A |
Description
Overview of the medicine
Stebet-CL Cream contains a potent corticosteroid (Clobetasol Propionate) and an antifungal agent (Clotrimazole). It is used to treat inflammatory skin conditions like eczema or psoriasis that are complicated by superficial fungal infections.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area once or twice daily, or as directed by the physician. Treatment should not exceed 2 weeks without medical review.
Elderly
No specific dosage adjustment required, but caution is advised due to potential thinning of skin.
Renal_impairment
No dosage adjustment required for topical application due to minimal systemic absorption.
How to Take
For external use only. Apply a thin film to the affected skin area and rub in gently. Wash hands before and after application. Avoid contact with eyes, nose, mouth, and other mucous membranes.
Mechanism of Action
Clobetasol Propionate is a highly potent corticosteroid that provides anti-inflammatory, antipruritic, and vasoconstrictive actions. Clotrimazole is an imidazole antifungal that works by inhibiting the biosynthesis of ergosterol, an essential component of the fungal cell membrane, leading to fungal cell death.
Pharmacokinetics
Onset
Symptomatic relief can begin within a few days of treatment.
Excretion
Clobetasol: Excreted primarily by the kidneys. Clotrimazole: Excreted predominantly in the feces (systemic absorption is minimal).
Half life
Clobetasol: Approximately 4-5 hours (systemic). Clotrimazole: Not applicable for topical, minimal systemic absorption.
Absorption
Clobetasol: Systemic absorption can occur, especially with prolonged use, extensive areas, or occlusive dressings. Clotrimazole: Poorly absorbed systemically following topical application.
Metabolism
Clobetasol: Primarily metabolized in the liver. Clotrimazole: Metabolized in the liver to inactive compounds (systemic absorption is minimal).
Side Effects
Contraindications
- •Hypersensitivity to Clobetasol, Clotrimazole, or any other component of the cream
- •Viral skin infections (e.g., herpes simplex, varicella)
- •Tuberculosis of the skin
- •Acne vulgaris, rosacea, perioral dermatitis
- •Vaccination reactions
- •Primary cutaneous fungal infections without inflammatory component
Drug Interactions
No significant interactions
No significant drug-drug interactions are typically reported for topical Clobetasol and Clotrimazole due to minimal systemic absorption.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic effects. However, prolonged and excessive use of Clobetasol may lead to systemic effects such as Cushing's syndrome or HPA axis suppression. In such cases, gradually withdraw the drug under medical supervision.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor before use. Avoid applying to the breast area during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved by national regulatory authorities
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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