Steson
Generic Name
Mometasone Furoate 0.05% w/w Cream
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| steson 005 cream | ৳ 41.00 | N/A |
Description
Overview of the medicine
Steson 0.05% Cream contains Mometasone Furoate, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It is used to treat various inflammatory and pruritic skin conditions.
Uses & Indications
Dosage
Adults
Apply a thin film of Steson 0.05% Cream to the affected skin areas once daily.
Elderly
No specific dosage adjustments are required for elderly patients. Use with caution due to potentially thinner skin and increased susceptibility to adverse effects.
Renal_impairment
No specific dosage adjustments are required for patients with renal impairment, as systemic absorption is minimal.
How to Take
For external use only. Apply a thin film to the affected skin areas once daily. Gently rub in until the medicine disappears. Do not use occlusive dressings unless directed by a physician. Avoid contact with eyes.
Mechanism of Action
Mometasone Furoate, a corticosteroid, diffuses across cell membranes and binds to specific cytoplasmic receptors. This complex then enters the nucleus, binds to DNA, and modifies gene expression, leading to the synthesis of proteins that inhibit the release of inflammatory mediators like prostaglandins and leukotrienes. It also induces lipocortins, which inhibit phospholipase A2.
Pharmacokinetics
Onset
Onset of symptomatic relief within a few days of initiation.
Excretion
Metabolites are excreted in urine and feces.
Half life
Not precisely determined for topical application; systemic half-life for absorbed drug is variable.
Absorption
Minimal systemic absorption (<0.1%) occurs after topical application, especially on intact skin. Absorption may increase with skin barrier damage, prolonged use, or occlusive dressings.
Metabolism
Any systemically absorbed Mometasone Furoate is primarily metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to Mometasone Furoate or any component of the cream
- •Bacterial, fungal, viral (e.g., herpes, varicella) or parasitic infections of the skin (unless concomitant antimicrobial therapy is used)
- •Acne rosacea
- •Perioral dermatitis
- •Perianal and genital pruritus
- •Ulcerative conditions
- •Vaccination reactions
Drug Interactions
CYP3A4 Inhibitors
Coadministration with CYP3A4 inhibitors (e.g., ritonavir, itraconazole) may increase systemic exposure to Mometasone Furoate, though significant interactions are unlikely with topical use.
Systemic Corticosteroids
Increased risk of systemic corticosteroid side effects if used concurrently over large areas or under occlusive dressings.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Prolonged use of excessive amounts of topical corticosteroids can suppress hypothalamic-pituitary-adrenal (HPA) axis function, leading to secondary adrenal insufficiency. Symptoms may include Cushing's syndrome, hyperglycemia, and glucosuria. Management involves gradual withdrawal of the drug and symptomatic treatment.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid extensive use or prolonged treatment. Use with caution during lactation, as it is not known whether topical corticosteroids are excreted in human milk. Avoid applying to the breast area.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
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Global Brand Names
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