Stogut
Generic Name
Saccharomyces boulardii
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| stogut 20 mg tablet | ৳ 5.02 | ৳ 50.16 |
Description
Overview of the medicine
Stogut is a probiotic preparation containing Saccharomyces boulardii, a non-pathogenic yeast. It is used to restore the natural balance of gut flora, effectively treating and preventing various types of diarrhea including antibiotic-associated diarrhea, traveler's diarrhea, and acute infectious diarrhea.
Uses & Indications
Dosage
Adults
1-2 capsules (250-500 mg) once or twice daily, or as directed by physician. For AAD, continue for 4 weeks after antibiotic cessation. For H. pylori, during antibiotic therapy.
Elderly
Same as adult dosage.
Renal_impairment
No dosage adjustment necessary.
How to Take
Capsules can be swallowed whole with water. For children or patients with difficulty swallowing, the contents of the capsule can be mixed with a small amount of water, juice, or food (not hot). Do not mix with very hot or alcoholic beverages.
Mechanism of Action
Saccharomyces boulardii exerts its action through multiple mechanisms: it binds to pathogens, inhibiting their adhesion and growth; neutralizes bacterial toxins; modulates the immune system; and maintains the integrity of the intestinal barrier. It also produces polyamines that stimulate brush border enzyme activity and nutrient absorption.
Pharmacokinetics
Onset
Effects typically observed within 1-2 days for diarrhea management.
Excretion
Excreted unchanged in feces within 2-5 days after discontinuation.
Half life
Not applicable as it's not absorbed systemically; however, it remains viable in the gut for several days after administration.
Absorption
Saccharomyces boulardii is a non-colonizing yeast, meaning it does not get absorbed into the bloodstream. It remains viable in the gastrointestinal tract.
Metabolism
Not applicable as it's a live organism and not metabolized by human enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Saccharomyces boulardii or any component of the formulation
- Patients with central venous catheter (risk of fungemia)
- Immunocompromised patients (risk of fungemia)
- Critically ill or hospitalized patients (risk of systemic infection)
Drug Interactions
Antifungal agents
Antifungal agents (oral or systemic) may inactivate Saccharomyces boulardii. Administer at a different time of day or avoid concomitant use if possible.
Storage
Store in a cool, dry place, below 25°C. Protect from light and moisture. Keep out of reach of children.
Overdose
No known specific symptoms of overdose. Saccharomyces boulardii is generally well-tolerated. Symptomatic and supportive measures should be taken if an overdose is suspected.
Pregnancy & Lactation
Generally considered safe. Studies have not shown adverse effects. Consult a doctor before use, especially during pregnancy and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from the manufacturing date when stored correctly.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by health authorities (e.g., DGDA, FDA as a dietary supplement/probiotic)
Patent Status
Generally off-patent for the strain, specific formulations may have patents
Clinical Trials
Numerous clinical trials support the efficacy of Saccharomyces boulardii in preventing and treating various forms of diarrhea, including meta-analyses demonstrating significant benefits.
Lab Monitoring
- No routine lab monitoring required. In patients at risk of fungemia, blood cultures may be monitored if systemic infection is suspected.
Doctor Notes
- Emphasize proper patient selection, especially avoiding use in severely immunocompromised or critically ill patients with central venous lines due to fungemia risk.
- Advise patients on appropriate administration (avoid hot liquids/alcohol).
- It does not replace rehydration therapy in cases of severe diarrhea.
Patient Guidelines
- Take as directed by your doctor or pharmacist.
- Do not exceed the recommended dose.
- Inform your doctor if you are pregnant, breastfeeding, or have a weakened immune system.
- Do not mix with very hot liquids or alcohol.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Saccharomyces boulardii is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hydration, especially during diarrhea.
- Follow a balanced diet.
- Practice good hand hygiene.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.