Stosec
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| stosec 20 mg capsule | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Stosec 20 mg Capsule contains Omeprazole, a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It is prescribed for conditions like heartburn, acid reflux, peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Usually 20 mg once daily before breakfast for 4-8 weeks. For severe cases or Zollinger-Ellison Syndrome, dosage may be increased up to 40 mg or more, sometimes twice daily.
Elderly
No specific dose adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule orally, preferably in the morning before breakfast. Swallow the capsule whole with water; do not chew or crush it.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase proton pump located in the gastric parietal cells. This action effectively blocks the final step in acid secretion, leading to a significant reduction in stomach acid production.
Pharmacokinetics
Onset
Acid suppression begins within 1 hour, maximal effect within 2 hours.
Excretion
Approximately 77% of the dose is excreted in the urine as metabolites, and the remainder in the feces.
Half life
Plasma elimination half-life is approximately 0.5-1 hour, but the duration of anti-secretory effect is much longer.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 0.5-3.5 hours. Bioavailability is about 30-40% but increases with repeated dosing.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 system (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Omeprazole, substituted benzimidazoles, or any component of the formulation.
- Co-administration with Nelfinavir (an antiviral drug).
Drug Interactions
Warfarin
Increased INR and bleeding risk.
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use).
Methotrexate
Increased plasma levels of methotrexate (monitor closely).
Diazepam, Phenytoin
Increased plasma levels of these drugs.
Nelfinavir, Atazanavir
Reduced plasma levels of these antivirals (contraindicated with nelfinavir).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and self-limiting, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if clearly needed. Omeprazole is excreted in breast milk; consult your doctor before breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole, substituted benzimidazoles, or any component of the formulation.
- Co-administration with Nelfinavir (an antiviral drug).
Drug Interactions
Warfarin
Increased INR and bleeding risk.
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use).
Methotrexate
Increased plasma levels of methotrexate (monitor closely).
Diazepam, Phenytoin
Increased plasma levels of these drugs.
Nelfinavir, Atazanavir
Reduced plasma levels of these antivirals (contraindicated with nelfinavir).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and self-limiting, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if clearly needed. Omeprazole is excreted in breast milk; consult your doctor before breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, specific expiry date is printed on the packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Globally Approved, DGDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Omeprazole has undergone extensive clinical trials demonstrating its efficacy and safety for various acid-related disorders. Ongoing research continues to explore its long-term effects and new therapeutic applications.
Lab Monitoring
- For long-term use (over 3 months), periodic monitoring of serum magnesium levels is recommended.
- Vitamin B12 levels may be monitored in patients at risk of deficiency due to prolonged use.
Doctor Notes
- Prescribe at the lowest effective dose for the shortest duration necessary.
- Consider assessing Vitamin B12 and magnesium levels in patients on long-term therapy.
- Counsel patients on potential drug interactions and lifestyle modifications.
Patient Guidelines
- Take the capsule whole; do not chew, crush, or open it.
- Take it preferably in the morning before a meal.
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Omeprazole may cause dizziness or visual disturbances in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy foods, fatty foods, caffeine, and acidic beverages.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed to reduce nighttime reflux.
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