Subazol
Generic Name
Pantoprazole
Manufacturer
Beacon Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| subazol 65 mg capsule | ৳ 20.00 | ৳ 120.00 |
Description
Overview of the medicine
Subazol is a proton pump inhibitor (PPI) containing Pantoprazole, used to reduce the amount of acid produced in the stomach. It treats conditions like heartburn, acid reflux, and stomach ulcers.
Uses & Indications
Dosage
Adults
Typically 40 mg once daily for 4-8 weeks for GERD/erosive esophagitis. For maintenance, 20-40 mg daily. For Zollinger-Ellison Syndrome, initial dose 40 mg twice daily, adjusted as needed.
Elderly
No dose adjustment generally required, but caution in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment necessary. Pantoprazole is not removed by hemodialysis.
How to Take
Take orally before a meal, preferably in the morning. Swallow whole, do not crush or chew. IV formulation is administered by healthcare professionals.
Mechanism of Action
Pantoprazole irreversibly binds to and inhibits the H+/K+-ATPase proton pump in gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 2.5 hours
Excretion
Primarily excreted in urine (approx. 80%) and feces (approx. 18%) as metabolites.
Half life
Approximately 1 hour
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 77%.
Metabolism
Extensively metabolized in the liver via cytochrome P450 (CYP2C19 and CYP3A4) system.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation.
- Hypersensitivity to other substituted benzimidazoles.
Drug Interactions
Clopidogrel
May reduce antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate levels and toxicity.
Drugs dependent on gastric pH for absorption (e.g., ketoconazole, atazanavir, nelfinavir)
May alter absorption.
Storage
Store below 30°C, in a dry place, away from light. Keep out of reach of children.
Overdose
Limited experience with overdose. Treatment is symptomatic and supportive. Pantoprazole is not dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, caution advised in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA, FDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of pantoprazole for various acid-related disorders.
Doctor Notes
- Advise patients on lifestyle modifications.
- Consider lowest effective dose for shortest duration.
- Monitor for long-term adverse effects if therapy is prolonged.
Patient Guidelines
- Take medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any unusual symptoms or side effects immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
May cause dizziness or visual disturbances; caution advised when driving or operating machinery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.