Sucomet
Generic Name
Sitagliptin + Metformin Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sucomet 500 mg tablet | ৳ 3.45 | ৳ 34.50 |
| sucomet 850 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Sucomet is a combination medicine containing Sitagliptin and Metformin, used to improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.
Uses & Indications
Dosage
Adults
Individualized. Typically Sitagliptin 50 mg/Metformin 500 mg, 850 mg or 1000 mg, once or twice daily with meals. Max Sitagliptin 100 mg/day.
Elderly
Careful dose adjustment based on renal function, starting with lower doses.
Renal_impairment
Contraindicated if eGFR < 30 mL/min/1.73m². Dose adjustment required for eGFR 30-60 mL/min/1.73m².
How to Take
Take orally with meals to reduce gastrointestinal side effects, especially for the Metformin component.
Mechanism of Action
Sitagliptin enhances incretin hormone levels, increasing insulin synthesis and release and decreasing glucagon secretion. Metformin decreases hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity by enhancing peripheral glucose uptake.
Pharmacokinetics
Onset
Metformin: within hours; Sitagliptin: within hours.
Excretion
Both primarily excreted unchanged in urine.
Half life
Sitagliptin: ~12.4 hours; Metformin: 4-9 hours.
Absorption
Sitagliptin is well absorbed orally (bioavailability ~87%), Metformin has an absolute bioavailability of 50-60%.
Metabolism
Sitagliptin: limited metabolism (CYP3A4); Metformin: not metabolized.
Side Effects
Contraindications
- •Severe renal impairment (eGFR < 30 mL/min/1.73m²).
- •Metabolic acidosis, including diabetic ketoacidosis.
- •Hypersensitivity to Sitagliptin or Metformin.
- •Acute or chronic metabolic acidosis.
Drug Interactions
Alcohol
Potentiates Metformin's effect on lactate metabolism, increasing lactic acidosis risk.
Iodinated contrast agents
Temporarily discontinue Metformin before or at the time of the procedure in patients with renal impairment.
Cationic drugs (e.g., cimetidine, amiloride)
May increase Metformin concentration.
Carbonic anhydrase inhibitors (e.g., topiramate)
May increase risk of lactic acidosis.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose of Metformin can lead to lactic acidosis, which requires immediate medical attention. Hemodialysis can be used to remove Metformin and Sitagliptin.
Pregnancy & Lactation
Not recommended during pregnancy and lactation unless clearly indicated and benefits outweigh risks. Insulin is generally preferred for glycemic control during pregnancy.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generics available
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Global Brand Names
International brand names for this medicine
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