Sucorid
Generic Name
Gliclazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sucorid 2 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Gliclazide is a sulfonylurea antidiabetic agent used in the management of non-insulin-dependent diabetes (Type 2) in adults, when diet, physical exercise and weight loss alone are not sufficient. It stimulates insulin secretion from pancreatic beta cells.
Uses & Indications
Dosage
Adults
Initial dose is typically 40-80 mg daily, taken before meals. Dose can be adjusted up to a maximum of 320 mg/day (for standard release). For MR formulations, 30-120 mg once daily, preferably with breakfast.
Elderly
Start with a lower dose and titrate carefully, monitoring blood glucose closely.
Renal_impairment
In mild to moderate renal impairment, dose adjustment may be necessary. Severe impairment is generally contraindicated.
How to Take
Standard release tablets are usually taken before meals. Modified Release (MR) tablets are usually taken once daily with breakfast.
Mechanism of Action
Gliclazide binds to sulfonylurea receptors on the pancreatic beta-cells, closing ATP-sensitive potassium channels. This depolarizes the cell, opening voltage-dependent calcium channels, leading to calcium influx and stimulation of insulin release. It also has some extra-pancreatic effects and microvascular benefits.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Primarily renal (60-70%) as metabolites, 10-20% fecal.
Half life
Approximately 8-20 hours (for standard release).
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma levels usually within 2-6 hours. Modified Release (MR) formulations have prolonged absorption.
Metabolism
Extensively metabolized in the liver (mainly by CYP2C9) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to gliclazide or other sulfonylureas
- Type 1 Diabetes Mellitus
- Diabetic pre-coma or coma, diabetic ketoacidosis
- Severe renal or hepatic insufficiency
- Concomitant use with miconazole
- Pregnancy and lactation
Drug Interactions
Miconazole
Potentiates hypoglycemic effect, leading to severe hypoglycemia.
Phenylbutazone, Alcohol
Enhance the hypoglycemic effect.
Danazol, Chlorpromazine, Corticosteroids, Diuretics
May reduce the hypoglycemic effect of gliclazide.
Beta-blockers, Fluconazole, ACE inhibitors, NSAIDs, Sulfonamides, Clarithromycin
May increase the risk of hypoglycemia.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypoglycemia. Management involves immediate administration of oral glucose if conscious, or intravenous glucose (dextrose) and glucagon if severe or unconscious. Close monitoring is required.
Pregnancy & Lactation
Gliclazide is contraindicated during pregnancy and lactation due to potential risks to the fetus/infant and the availability of safer alternatives (e.g., insulin).
Side Effects
Contraindications
- Hypersensitivity to gliclazide or other sulfonylureas
- Type 1 Diabetes Mellitus
- Diabetic pre-coma or coma, diabetic ketoacidosis
- Severe renal or hepatic insufficiency
- Concomitant use with miconazole
- Pregnancy and lactation
Drug Interactions
Miconazole
Potentiates hypoglycemic effect, leading to severe hypoglycemia.
Phenylbutazone, Alcohol
Enhance the hypoglycemic effect.
Danazol, Chlorpromazine, Corticosteroids, Diuretics
May reduce the hypoglycemic effect of gliclazide.
Beta-blockers, Fluconazole, ACE inhibitors, NSAIDs, Sulfonamides, Clarithromycin
May increase the risk of hypoglycemia.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypoglycemia. Management involves immediate administration of oral glucose if conscious, or intravenous glucose (dextrose) and glucagon if severe or unconscious. Close monitoring is required.
Pregnancy & Lactation
Gliclazide is contraindicated during pregnancy and lactation due to potential risks to the fetus/infant and the availability of safer alternatives (e.g., insulin).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of gliclazide in managing Type 2 Diabetes Mellitus. Studies like ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation) have explored its cardiovascular outcomes.
Lab Monitoring
- Regular monitoring of blood glucose levels
- HbA1c monitoring
- Renal function tests
- Liver function tests
Doctor Notes
- Educate patients thoroughly about hypoglycemia symptoms and management.
- Emphasize lifestyle modifications (diet, exercise) as foundational therapy.
- Regularly monitor blood glucose and HbA1c to assess treatment effectiveness.
- Consider renal and hepatic function, especially in elderly patients.
Patient Guidelines
- Take medicine exactly as prescribed by your doctor.
- Adhere to recommended diet and exercise plan.
- Monitor blood glucose regularly as advised.
- Learn to recognize and treat symptoms of hypoglycemia.
- Carry a source of sugar (e.g., glucose tablets, juice) for emergency.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Patients should be aware of the risk of hypoglycemia, especially at the start of treatment, with dose changes, or if meals are missed. Drive or operate machinery with caution.
Lifestyle Advice
- Maintain a balanced diet and regular meal times.
- Engage in regular physical activity.
- Achieve and maintain a healthy weight.
- Avoid excessive alcohol consumption.
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