Sulinzen
Generic Name
Sulinzen 200 mg Tablet
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sulinzen 200 mg tablet | ৳ 8.50 | ৳ 85.00 |
Description
Overview of the medicine
Sulinzen 200 mg Tablet is a medication primarily used to relieve pain, reduce inflammation, and lower fever. It belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) and works by blocking the production of certain natural substances in the body that cause inflammation and pain.
Uses & Indications
Dosage
Adults
The usual adult dose is 200 mg once daily, or 100 mg twice daily, as directed by a physician. Max daily dose: 400 mg.
Elderly
Elderly patients should use with caution, usually starting at a lower dose (e.g., 100 mg once daily) and titrated based on response and tolerability, due to increased risk of side effects.
Renal_impairment
For patients with mild to moderate renal impairment, dose adjustment may be necessary. Not recommended for severe renal impairment (CrCl < 30 mL/min).
How to Take
Take the tablet orally with water, preferably after a meal to minimize gastrointestinal upset. Do not chew or crush the tablet.
Mechanism of Action
Sulinzen acts by inhibiting cyclooxygenase (COX) enzymes, primarily COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are lipid compounds that mediate inflammation, pain, and fever. By reducing prostaglandin levels, Sulinzen alleviates these symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesic effect.
Excretion
Mainly excreted in urine (approximately 65%) and feces (approximately 35%) as metabolites.
Half life
Approximately 4-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-3 hours.
Metabolism
Primarily hepatic metabolism, extensively metabolized by cytochrome P450 enzymes (e.g., CYP2C9).
Side Effects
Contraindications
- Known hypersensitivity to Sulinzen or any other NSAID
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate levels, leading to toxicity.
ACE inhibitors/ARBs
Increased risk of renal impairment, reduced antihypertensive effect.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, and possibly acute renal failure. Management involves symptomatic and supportive care; gastric lavage and activated charcoal may be considered within the first few hours.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential effects on fetal cardiovascular system. Use during first two trimesters and lactation only if clearly necessary and potential benefits outweigh risks, under medical supervision.
Side Effects
Contraindications
- Known hypersensitivity to Sulinzen or any other NSAID
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate levels, leading to toxicity.
ACE inhibitors/ARBs
Increased risk of renal impairment, reduced antihypertensive effect.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, and possibly acute renal failure. Management involves symptomatic and supportive care; gastric lavage and activated charcoal may be considered within the first few hours.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential effects on fetal cardiovascular system. Use during first two trimesters and lactation only if clearly necessary and potential benefits outweigh risks, under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent Pending
Clinical Trials
Ongoing clinical trials are investigating the long-term safety profile and efficacy in specific patient populations. No major ongoing trials for new indications currently.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- Blood pressure monitoring
Doctor Notes
- Advise patients to report any signs of gastrointestinal bleeding (e.g., black tarry stools).
- Caution in patients with a history of hypertension, heart failure, or renal dysfunction.
- Regularly assess the need for continued therapy, especially in chronic conditions.
Patient Guidelines
- Take Sulinzen with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding, black stools, or severe abdominal pain immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness; if affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid excessive alcohol consumption while taking Sulinzen.
- Maintain adequate hydration.
- For chronic pain, consider physiotherapy or other non-pharmacological therapies.
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Global Brand Names
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