Supadopa TR
Generic Name
Levodopa and Carbidopa Extended-Release
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| supadopa tr 2375 mg capsule | ৳ 30.00 | ৳ 180.00 |
| supadopa tr 3625 mg capsule | ৳ 40.00 | ৳ 240.00 |
| supadopa tr 4875 mg capsule | ৳ 50.00 | ৳ 300.00 |
| supadopa tr 6125 mg capsule | ৳ 60.00 | ৳ 360.00 |
Description
Overview of the medicine
Supadopa TR is an extended-release medication containing levodopa and carbidopa, used to treat Parkinson's disease symptoms such as tremor, rigidity, and slow movement. The extended-release formulation helps to provide a more sustained therapeutic effect.
Uses & Indications
Dosage
Adults
Dosage must be individualized. Typically starting with 100 mg levodopa / 25 mg carbidopa twice daily, adjusted every few days as needed, up to a maximum of 1600 mg levodopa / 400 mg carbidopa per day.
Elderly
Similar to adult dosage, but titration should be done carefully due to increased sensitivity and potential for side effects.
Renal_impairment
No specific dosage adjustment recommended for mild to moderate renal impairment, but caution is advised. Not studied in severe renal impairment.
How to Take
Oral administration. Tablets should be swallowed whole, not crushed, chewed, or divided. Can be taken with or without food, but food may delay absorption.
Mechanism of Action
Levodopa is converted to dopamine in the brain, which helps to alleviate Parkinson's symptoms by replenishing dopamine levels. Carbidopa inhibits peripheral dopa decarboxylase, preventing levodopa breakdown outside the brain, thus increasing the amount of levodopa available to cross the blood-brain barrier and reducing peripheral side effects.
Pharmacokinetics
Onset
Approximately 30-60 minutes for initial effect, peak plasma levels typically reached in 2-3 hours with TR form.
Excretion
Primarily excreted renally as metabolites.
Half life
Levodopa: approximately 1.5-2 hours (extended for TR). Carbidopa: approximately 2-3 hours.
Absorption
Levodopa is absorbed from the small intestine. Carbidopa enhances levodopa bioavailability. Extended-release formulation provides slower and more sustained absorption.
Metabolism
Levodopa is extensively metabolized in the periphery and CNS, primarily via decarboxylation and O-methylation. Carbidopa is also metabolized but pathways are not fully elucidated.
Side Effects
Contraindications
- Narrow-angle glaucoma
- Concomitant use with non-selective monoamine oxidase (MAO) inhibitors
- Suspicious undiagnosed skin lesions or a history of melanoma
Drug Interactions
Iron salts
May reduce the bioavailability of levodopa.
Non-selective MAO inhibitors
May cause hypertensive crisis. Should be discontinued at least 2 weeks prior to initiating levodopa/carbidopa.
Phenothiazines, butyrophenones, reserpine, metoclopramide
May reduce the therapeutic effects of levodopa.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include acute dyskinesias, nausea, vomiting, cardiac arrhythmias. Management involves gastric lavage, supportive measures, and careful monitoring.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if levodopa/carbidopa is excreted in human milk; caution advised.
Side Effects
Contraindications
- Narrow-angle glaucoma
- Concomitant use with non-selective monoamine oxidase (MAO) inhibitors
- Suspicious undiagnosed skin lesions or a history of melanoma
Drug Interactions
Iron salts
May reduce the bioavailability of levodopa.
Non-selective MAO inhibitors
May cause hypertensive crisis. Should be discontinued at least 2 weeks prior to initiating levodopa/carbidopa.
Phenothiazines, butyrophenones, reserpine, metoclopramide
May reduce the therapeutic effects of levodopa.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include acute dyskinesias, nausea, vomiting, cardiac arrhythmias. Management involves gastric lavage, supportive measures, and careful monitoring.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if levodopa/carbidopa is excreted in human milk; caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of levodopa/carbidopa in Parkinson's disease, including studies specifically on extended-release formulations demonstrating reduced 'off' time and motor fluctuations.
Lab Monitoring
- Periodic evaluation of hepatic, renal, and hematopoietic function is recommended during extended therapy.
Doctor Notes
- Emphasize slow titration to minimize adverse effects.
- Monitor for psychiatric symptoms and dyskinesias.
- Educate patients on the importance of consistent dosing and not crushing tablets.
Patient Guidelines
- Do not stop taking this medication abruptly without consulting your doctor.
- Take the medication regularly as prescribed to maintain stable symptom control.
- Report any new or worsening involuntary movements or psychiatric symptoms to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not double the dose to catch up.
Driving Precautions
May cause drowsiness, dizziness, or sudden onset of sleep. Patients should be warned about driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a balanced diet, but be mindful of high-protein meals affecting absorption.
- Regular exercise, as tolerated, can help manage Parkinson's symptoms.
- Avoid sudden changes in posture to reduce orthostatic hypotension.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.