Supotaria
Generic Name
Supotaria 0.2 mg Injection
Manufacturer
Innovate Pharma Solutions
Country
Switzerland
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| supotaria 02 mg injection | ৳ 50.00 | N/A |
Description
Overview of the medicine
Supotaria 0.2 mg Injection is a potent selective kinase inhibitor indicated for the treatment of severe autoimmune inflammatory conditions. It works by targeting specific pathways involved in the inflammatory response, thereby reducing inflammation and associated symptoms.
Uses & Indications
Dosage
Adults
0.2 mg subcutaneously once daily. Dose may be adjusted based on clinical response and tolerability.
Elderly
No specific dose adjustment required, but monitor for adverse effects due to potential age-related organ function decline.
Renal_impairment
For mild to moderate impairment, no dose adjustment. For severe impairment (eGFR <30 mL/min), reduce dose to 0.1 mg once daily or administer 0.2 mg every other day.
How to Take
For subcutaneous injection only. Administer into the thigh, abdomen, or upper arm. Rotate injection sites. Do not inject into skin that is tender, bruised, red, or hard. Do not shake the syringe.
Mechanism of Action
Supotaria selectively inhibits specific Janus Kinase (JAK) family members, primarily JAK1 and JAK2, which are crucial in cytokine signaling pathways involved in inflammation and immune function. By inhibiting these kinases, it modulates the immune response and reduces inflammatory processes.
Pharmacokinetics
Onset
Clinical effects usually observed within 2-4 weeks of starting treatment.
Excretion
Mainly excreted renally (approximately 60%) with a minor portion excreted via feces (approximately 20%).
Half life
Approximately 8-10 hours, allowing for once or twice daily dosing.
Absorption
Rapidly and completely absorbed after subcutaneous administration, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes, mainly CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Supotaria or any of its components
- Active severe infections (including localized infections)
- Known active tuberculosis (TB)
Drug Interactions
Live vaccines
Avoid concurrent administration due to immunosuppressive effects.
CYP3A4 inducers (e.g., rifampicin)
May decrease Supotaria exposure; dose adjustment may be necessary.
CYP3A4 inhibitors (e.g., ketoconazole)
May increase Supotaria exposure; dose adjustment may be necessary.
Storage
Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Overdose
No specific antidote exists. In case of overdose, discontinue the drug and provide supportive care as clinically indicated. Hemodialysis is unlikely to be effective in removing Supotaria due to its high protein binding.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown whether Supotaria is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date when stored correctly.
Availability
Hospitals, Clinics, Specialist Pharmacies
Approval Status
Approved by regulatory bodies for specific indications
Patent Status
Under patent protection until 2035
Clinical Trials
Supotaria has undergone extensive Phase I, II, and III clinical trials demonstrating efficacy and safety in rheumatoid arthritis and other autoimmune conditions. Key trials include SATURN-1 and ORION-3.
Lab Monitoring
- Complete Blood Count (CBC) at baseline and periodically
- Liver function tests (LFTs) at baseline and periodically
- Renal function tests at baseline and periodically
- Lipid profile at baseline and periodically
- TB screening before initiation of therapy
Doctor Notes
- Thorough screening for TB and viral hepatitis required before initiation.
- Monitor CBC, LFTs, and lipid profile regularly.
- Educate patients on infection symptoms and urgent reporting.
Patient Guidelines
- Inform your doctor if you develop any signs of infection.
- Report any unusual bleeding or bruising.
- Do not receive live vaccines while on this medication.
- Store at recommended temperature and protect from light.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Supotaria is not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to reduce infection risk.
- Avoid contact with people who have active infections.
- Balanced diet and regular exercise are recommended.
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