Susten
Generic Name
Progesterone
Manufacturer
Sun Pharmaceutical Industries Ltd.
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| susten 60 mg tablet | ৳ 50.00 | ৳ 250.00 |
Description
Overview of the medicine
Susten 60 mg Tablet contains Progesterone, a naturally occurring female hormone. It is primarily used to treat various conditions related to hormonal imbalance, including menstrual disorders, secondary amenorrhea, and to support pregnancy in certain cases.
Uses & Indications
Dosage
Adults
For secondary amenorrhea: 60 mg once daily for 5-10 days, starting on day 16 or 21 of the menstrual cycle. For luteal phase support: Dosage varies greatly, typically 60 mg to 200 mg daily. Consult physician.
Elderly
Use with caution, dosage adjustments may be required due to hepatic or renal impairment.
Renal_impairment
Use with caution, dosage adjustments may be required; consult physician.
How to Take
Take the tablet orally with water, preferably at bedtime to minimize dizziness and drowsiness. May be taken with or without food.
Mechanism of Action
Progesterone is a natural progestin. It binds to progesterone receptors in the uterus, mammary glands, hypothalamus, and pituitary gland. It induces secretory changes in the endometrium, preparing it for embryo implantation, and maintains pregnancy by suppressing uterine contractility.
Pharmacokinetics
Onset
Variable, typically within hours for uterine effects.
Excretion
Primarily renal (kidney) as metabolites, with some biliary excretion.
Half life
25-50 hours (for micronized oral progesterone).
Absorption
Well absorbed after oral administration, but undergoes significant first-pass metabolism. Bioavailability is low.
Metabolism
Primarily hepatic (liver) by reduction and conjugation, forming various metabolites.
Side Effects
Contraindications
- Known hypersensitivity to progesterone or any component of the tablet
- Undiagnosed vaginal bleeding
- Severe liver disease
- History of thromboembolic disorders
- Known or suspected breast cancer or other hormone-sensitive cancers
Drug Interactions
Warfarin
Progesterone may affect anticoagulant activity.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase progesterone levels, potentially leading to increased side effects.
CYP3A4 inducers (e.g., Rifampicin, Carbamazepine, Phenytoin)
May decrease progesterone levels, reducing its efficacy.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, nausea, and vomiting. Treatment is symptomatic and supportive. No specific antidote.
Pregnancy & Lactation
Often used to support pregnancy in cases of progesterone deficiency or ART. Generally considered safe for use in early pregnancy under medical supervision. Excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA for other strengths)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have supported the efficacy and safety of progesterone for its approved indications, especially in reproductive health and hormone replacement therapy.
Lab Monitoring
- Liver function tests (periodically, especially with prolonged use or history of liver issues)
- Blood glucose levels (in diabetic patients)
- Progesterone levels (if indicated for specific conditions)
Doctor Notes
- Ensure patient is not pregnant before starting treatment for secondary amenorrhea.
- Monitor for signs of thromboembolic events.
- Advise patients on potential side effects like dizziness and how to manage them.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking it suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any unusual or severe side effects immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking and excessive alcohol consumption, as these can affect hormone levels and overall health.
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