Adults

Apply a thin layer of gel to the affected area 2-3 times daily, or as directed by the physician.

Elderly

No special dosage adjustment is required for elderly patients; use as for adults.

Renal_impairment

No specific dosage adjustment is required for topical application in patients with renal impairment.

Onset

Local counter-irritant effect within minutes; analgesic and anti-inflammatory effects develop over a few hours.

Excretion

Systemically absorbed aceclofenac metabolites are excreted in urine and faeces. Salicylic acid metabolites are primarily excreted renally.

Half life

Systemic half-life of aceclofenac is about 4 hours. Methyl salicylate is rapidly metabolized to salicylic acid.

Absorption

Minimal systemic absorption after topical application; primarily acts locally. A small fraction of aceclofenac and methyl salicylate may be absorbed systemically.

Metabolism

Aceclofenac undergoes extensive metabolism to its hydroxylated derivatives. Methyl salicylate is metabolized to salicylic acid, primarily in the skin and liver.

Other NSAIDs (systemic)

Concomitant use with oral NSAIDs may increase the risk of systemic adverse effects, though unlikely with typical topical application.

Lithium and Methotrexate

Increased plasma concentrations and toxicity are theoretically possible if significant systemic absorption occurs, but highly improbable with normal topical use.

Oral Anticoagulants (e.g., Warfarin)

Although systemic absorption is minimal, theoretical risk of increased bleeding due to additive effects, especially with prolonged or extensive use.