Suxen
Generic Name
Aceclofenac + Methyl Salicylate
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| suxen 10 w gel | ৳ 62.00 | N/A |
Description
Overview of the medicine
Suxen-10-W Gel is a topical preparation containing Aceclofenac, an NSAID, and Methyl Salicylate, a counter-irritant. It is used for localized pain and inflammation associated with musculoskeletal conditions.
Uses & Indications
Dosage
Adults
Apply a thin layer of gel to the affected area 2-3 times daily, or as directed by the physician.
Elderly
No special dosage adjustment is required for elderly patients; use as for adults.
Renal_impairment
No specific dosage adjustment is required for topical application in patients with renal impairment.
How to Take
For external use only. Apply a thin layer evenly to the intact skin over the affected area. Gently rub until absorbed. Wash hands thoroughly after application. Do not apply to open wounds, infected skin, eyes, or mucous membranes.
Mechanism of Action
Aceclofenac inhibits prostaglandin synthesis by blocking cyclooxygenase (COX) enzymes, thereby reducing inflammation, pain, and fever. Methyl Salicylate acts as a counter-irritant, producing a sensation of warmth that distracts from the pain and may cause local vasodilation, aiding blood flow to the affected area.
Pharmacokinetics
Onset
Local counter-irritant effect within minutes; analgesic and anti-inflammatory effects develop over a few hours.
Excretion
Systemically absorbed aceclofenac metabolites are excreted in urine and faeces. Salicylic acid metabolites are primarily excreted renally.
Half life
Systemic half-life of aceclofenac is about 4 hours. Methyl salicylate is rapidly metabolized to salicylic acid.
Absorption
Minimal systemic absorption after topical application; primarily acts locally. A small fraction of aceclofenac and methyl salicylate may be absorbed systemically.
Metabolism
Aceclofenac undergoes extensive metabolism to its hydroxylated derivatives. Methyl salicylate is metabolized to salicylic acid, primarily in the skin and liver.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac, methyl salicylate, aspirin, or any other NSAID.
- Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- Application to open wounds, damaged skin, infected areas, eyes, or mucous membranes.
- Third trimester of pregnancy.
Drug Interactions
Other NSAIDs (systemic)
Concomitant use with oral NSAIDs may increase the risk of systemic adverse effects, though unlikely with typical topical application.
Lithium and Methotrexate
Increased plasma concentrations and toxicity are theoretically possible if significant systemic absorption occurs, but highly improbable with normal topical use.
Oral Anticoagulants (e.g., Warfarin)
Although systemic absorption is minimal, theoretical risk of increased bleeding due to additive effects, especially with prolonged or extensive use.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is unlikely with topical application. Accidental ingestion may lead to systemic NSAID adverse effects (e.g., gastrointestinal upset, renal dysfunction). Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if ingested recently.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential effects on fetal cardiovascular system. Use with caution during the first and second trimesters and during lactation only if the potential benefit outweighs the potential risk to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac, methyl salicylate, aspirin, or any other NSAID.
- Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- Application to open wounds, damaged skin, infected areas, eyes, or mucous membranes.
- Third trimester of pregnancy.
Drug Interactions
Other NSAIDs (systemic)
Concomitant use with oral NSAIDs may increase the risk of systemic adverse effects, though unlikely with typical topical application.
Lithium and Methotrexate
Increased plasma concentrations and toxicity are theoretically possible if significant systemic absorption occurs, but highly improbable with normal topical use.
Oral Anticoagulants (e.g., Warfarin)
Although systemic absorption is minimal, theoretical risk of increased bleeding due to additive effects, especially with prolonged or extensive use.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is unlikely with topical application. Accidental ingestion may lead to systemic NSAID adverse effects (e.g., gastrointestinal upset, renal dysfunction). Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if ingested recently.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential effects on fetal cardiovascular system. Use with caution during the first and second trimesters and during lactation only if the potential benefit outweighs the potential risk to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (generic ingredients)
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of topical aceclofenac and methyl salicylate in reducing pain and inflammation associated with various musculoskeletal conditions.
Lab Monitoring
- Not routinely required for topical application unless systemic absorption is suspected or adverse effects manifest.
Doctor Notes
- Remind patients that this product is for external use only and should not be ingested.
- Advise patients to report any severe skin irritation or signs of systemic reactions.
- Counsel on avoiding application to broken skin, eyes, and mucous membranes.
Patient Guidelines
- Ensure skin is clean and dry before application.
- Apply only to intact skin; do not use on open wounds, cuts, or damaged skin.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Wash hands thoroughly after applying the gel, unless your hands are the treated area.
- Do not cover the treated area with occlusive bandages or dressings unless advised by a doctor.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Suxen-10-W Gel is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- For chronic pain, consider combining topical treatment with physical therapy, exercise, and maintaining a healthy lifestyle. Avoid strenuous activities that aggravate pain.
- If sun exposure is unavoidable, protect the treated skin area from direct sunlight to minimize photosensitivity reactions.
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