Sylvia ODT
Generic Name
Desvenlafaxine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sylvia odt 75 mg tablet | ৳ 150.00 | ৳ 600.00 |
Description
Overview of the medicine
Desvenlafaxine is an antidepressant used to treat Major Depressive Disorder (MDD). It helps restore the balance of certain natural substances (serotonin and norepinephrine) in the brain, improving mood and other symptoms of depression.
Uses & Indications
Dosage
Adults
The recommended starting dose is 50 mg once daily. Dosage may be increased to 75 mg, 100 mg, 200 mg, or up to 400 mg once daily based on clinical response and tolerability. The 75 mg ODT is often used when a higher starting dose or an intermediate dose is desired.
Elderly
No specific dose adjustment is required, but caution is advised due to potential age-related decrease in renal clearance. Start with a lower dose and monitor carefully.
Renal_impairment
Moderate impairment (CrCl 30-50 mL/min): 50 mg every other day. Severe impairment (CrCl <30 mL/min) or End-Stage Renal Disease (ESRD) on hemodialysis: 50 mg twice weekly.
How to Take
Place the orally disintegrating tablet on the tongue and allow it to dissolve completely, then swallow with or without water. Take once daily, with or without food, at approximately the same time each day.
Mechanism of Action
Desvenlafaxine works by selectively inhibiting the reuptake of serotonin and norepinephrine in the brain, thereby increasing the availability of these neurotransmitters in the synaptic cleft, which helps to improve mood and reduce symptoms of depression.
Pharmacokinetics
Onset
Therapeutic effects may take 2-4 weeks to become noticeable.
Excretion
Primarily excreted renally (approximately 45% as unchanged drug, 19% as O-desmethylated metabolite).
Half life
Approximately 10-12 hours.
Absorption
Well absorbed orally, approximately 80% bioavailability. Peak plasma concentrations are reached in about 7.5 hours.
Metabolism
Primarily undergoes O-demethylation (minor contribution from CYP3A4). It is not extensively metabolized by CYP450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to desvenlafaxine or any component of the formulation.
- Concomitant use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
Drug Interactions
Alcohol
Avoid concurrent use, as it may enhance CNS depressant effects.
Monoamine Oxidase Inhibitors (MAOIs)
Serious, potentially fatal reactions including serotonin syndrome. Do not use within 14 days of stopping an MAOI, or within 7 days of stopping desvenlafaxine before starting an MAOI.
Drugs that affect hemostasis (e.g., NSAIDs, aspirin, warfarin)
Increased risk of bleeding.
Serotonergic drugs (e.g., SSRIs, other SNRIs, triptans, tramadol, St. John's wort)
Increased risk of serotonin syndrome.
Storage
Store at room temperature (below 25°C), away from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, increased heart rate, dilated pupils, vomiting, and seizures. Management involves supportive and symptomatic treatment, maintaining an open airway, and monitoring cardiac and vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desvenlafaxine is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to desvenlafaxine or any component of the formulation.
- Concomitant use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
Drug Interactions
Alcohol
Avoid concurrent use, as it may enhance CNS depressant effects.
Monoamine Oxidase Inhibitors (MAOIs)
Serious, potentially fatal reactions including serotonin syndrome. Do not use within 14 days of stopping an MAOI, or within 7 days of stopping desvenlafaxine before starting an MAOI.
Drugs that affect hemostasis (e.g., NSAIDs, aspirin, warfarin)
Increased risk of bleeding.
Serotonergic drugs (e.g., SSRIs, other SNRIs, triptans, tramadol, St. John's wort)
Increased risk of serotonin syndrome.
Storage
Store at room temperature (below 25°C), away from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, increased heart rate, dilated pupils, vomiting, and seizures. Management involves supportive and symptomatic treatment, maintaining an open airway, and monitoring cardiac and vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desvenlafaxine is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Desvenlafaxine has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of Major Depressive Disorder.
Lab Monitoring
- Monitor blood pressure regularly, especially during initial treatment and dose escalation.
- Monitor heart rate.
- Monitor serum sodium levels, especially in elderly patients or those on diuretics, due to risk of hyponatremia.
Doctor Notes
- Regular blood pressure monitoring is crucial, especially in patients with pre-existing hypertension.
- Patients should be counselled about the risk of serotonin syndrome and withdrawal symptoms if treatment is abruptly discontinued.
- Consider a gradual dose reduction when discontinuing treatment to minimize withdrawal effects.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and do not stop abruptly.
- Report any unusual mood changes, worsening depression, or suicidal thoughts to your doctor immediately.
- It may take several weeks for the full therapeutic effect to be observed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Desvenlafaxine may cause dizziness, drowsiness, or blurred vision. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that the drug does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication.
- Maintain a healthy lifestyle, including regular exercise and a balanced diet.
- Ensure adequate sleep.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.