Syndol Plus
Generic Name
Paracetamol + Codeine Phosphate + Doxylamine Succinate + Caffeine
Manufacturer
GlaxoSmithKline
Country
United Kingdom
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| syndol plus 325 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Syndol Plus 325 mg Tablet is a combination analgesic used for the relief of moderate to severe pain. It contains Paracetamol to reduce pain and fever, Codeine Phosphate for stronger pain relief, Doxylamine Succinate for its sedative/antihistamine effect, and Caffeine as an adjuvant to enhance the analgesic effect.
Uses & Indications
Dosage
Adults
1-2 tablets every 4-6 hours as needed, not exceeding 8 tablets in 24 hours.
Elderly
May require lower doses due to reduced renal or hepatic function. Close monitoring is advised.
Renal_impairment
Dose adjustment and increased dosing interval may be necessary based on creatinine clearance.
How to Take
Take orally with water, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Paracetamol inhibits prostaglandin synthesis in the central nervous system (CNS). Codeine acts as an opioid agonist, binding to mu-opioid receptors. Doxylamine is an H1-receptor antagonist with sedative properties. Caffeine acts as a CNS stimulant, inhibiting phosphodiesterase and enhancing the analgesic effect of other components.
Pharmacokinetics
Onset
Analgesic effects typically begin within 30-60 minutes.
Excretion
Mainly renal excretion of unchanged drug and metabolites.
Half life
Paracetamol 1-4 hours, Codeine 2.5-4 hours, Doxylamine 10-12 hours, Caffeine 3-7 hours.
Absorption
All active components are well absorbed orally. Paracetamol peak plasma concentrations are reached in 30-60 minutes, Codeine in about 60 minutes, Doxylamine in 2-3 hours, and Caffeine in 30-60 minutes.
Metabolism
Primarily hepatic. Paracetamol undergoes glucuronidation and sulfation. Codeine is metabolized to morphine via CYP2D6. Doxylamine and Caffeine are also metabolized in the liver (Caffeine via CYP1A2).
Side Effects
Contraindications
- •Hypersensitivity to any of the active ingredients or excipients
- •Acute respiratory depression
- •Children under 12 years (due to codeine)
- •Severe liver disease
- •Concurrent use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of stopping them
- •Alcohol intoxication
- •Head injury or increased intracranial pressure
Drug Interactions
MAOIs
Concurrent use may lead to serotonin syndrome.
Alcohol
Increased CNS depression, increased risk of hepatotoxicity (with paracetamol).
Anticoagulants (e.g., Warfarin)
Paracetamol may enhance the anticoagulant effect of warfarin with prolonged use.
CYP2D6 Inhibitors (e.g., quinidine, fluoxetine)
May reduce the efficacy of codeine by inhibiting its conversion to morphine.
Antihistamines (e.g., other sedating antihistamines)
Increased sedative effects due to doxylamine.
Other CNS Depressants (e.g., benzodiazepines, other opioids, sedatives)
Increased sedation, respiratory depression, hypotension, and profound sleep.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, respiratory depression, pinpoint pupils, cold and clammy skin, profound weakness, liver damage (from paracetamol), tachycardia (from caffeine), anticholinergic effects (from doxylamine). Management involves gastric lavage, activated charcoal, N-acetylcysteine for paracetamol toxicity, and naloxone for opioid effects. Supportive care is essential.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester, due to the presence of codeine (risk of neonatal withdrawal syndrome) and doxylamine (sedation). Consult a doctor before use during lactation as all active ingredients pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies and Hospitals
Approval Status
Approved
Patent Status
Generic available, original patent expired
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in