Synflex
Generic Name
Naproxen 250 mg tablet
Manufacturer
Various Pharmaceutical Companies
Country
Global / Various
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| synflex 250 mg tablet | ৳ 8.50 | ৳ 51.00 |
Description
Overview of the medicine
Synflex 250 mg tablet contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions like arthritis, menstrual cramps, and acute injuries.
Uses & Indications
Dosage
Adults
For rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: 250-500 mg twice daily. Maximum initial daily dose: 1250 mg; maximum subsequent daily dose: 1000 mg. For acute pain, dysmenorrhea, acute tendinitis, bursitis: 500 mg initially, then 250 mg every 6-8 hours as needed.
Elderly
Use the lowest effective dose for the shortest duration. Monitor for adverse effects, particularly renal and gastrointestinal.
Renal_impairment
Dose reduction is necessary in patients with mild to moderate renal impairment. Avoid in severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Take Synflex 250 mg tablet orally, preferably with food, milk, or an antacid to reduce the risk of gastrointestinal upset. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break it.
Mechanism of Action
Naproxen works by reversibly inhibiting the cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin production, naproxen effectively reduces these symptoms.
Pharmacokinetics
Onset
Analgesic effects typically begin within 1-2 hours; anti-inflammatory effects may take longer (up to 2 weeks for chronic conditions).
Excretion
Primarily excreted in the urine (approximately 95%) as unchanged naproxen, 6-O-desmethylnaproxen, and their conjugates; a small amount is excreted in feces.
Half life
Approximately 12-17 hours, allowing for twice-daily dosing.
Absorption
Rapid and complete absorption from the gastrointestinal tract, with peak plasma concentrations occurring within 2-4 hours after oral administration.
Metabolism
Extensively metabolized in the liver by demethylation to 6-O-desmethylnaproxen, followed by glucuronide conjugation of both the parent and metabolite.
Side Effects
Contraindications
- Known hypersensitivity to naproxen, aspirin, or other NSAIDs
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Naproxen can increase plasma lithium levels, leading to toxicity.
Methotrexate
Naproxen can increase methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of GI bleeding and potentially reduced cardioprotective effects of aspirin.
ACE Inhibitors / Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, indigestion, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered if ingested recently. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in late pregnancy due to potential effects on fetal cardiovascular system. Use with caution during lactation as naproxen is excreted in small amounts into breast milk. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to naproxen, aspirin, or other NSAIDs
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Naproxen can increase plasma lithium levels, leading to toxicity.
Methotrexate
Naproxen can increase methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of GI bleeding and potentially reduced cardioprotective effects of aspirin.
ACE Inhibitors / Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, indigestion, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered if ingested recently. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in late pregnancy due to potential effects on fetal cardiovascular system. Use with caution during lactation as naproxen is excreted in small amounts into breast milk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Refer to the packaging for exact expiry date.
Availability
Pharmacies nationwide
Approval Status
Approved (for Naproxen)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Naproxen has been extensively studied in numerous clinical trials establishing its efficacy and safety for various pain and inflammatory conditions over several decades.
Lab Monitoring
- Regular monitoring of renal function (serum creatinine, BUN)
- Liver function tests (ALT, AST) periodically, especially with long-term use
- Complete blood count (CBC) for signs of anemia or blood dyscrasias
- Blood pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs and symptoms of GI bleeding, cardiovascular events, and renal impairment.
- Consider gastroprotective agents in high-risk patients.
- Advise patients on appropriate administration with food/milk.
Patient Guidelines
- Take with food or milk to minimize stomach upset.
- Do not exceed the prescribed dose or duration of use.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools, vomiting blood) immediately.
- Be aware of the potential cardiovascular risks.
- Avoid concomitant use with other NSAIDs.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Synflex may cause dizziness or drowsiness in some individuals. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Avoid excessive alcohol consumption while taking this medication.
- Maintain a balanced diet and stay hydrated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.