Tabrex
Generic Name
Levofloxacin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tabrex 500 mg tablet | ৳ 30.00 | N/A |
Description
Overview of the medicine
Levofloxacin is a fluoroquinolone antibiotic used to treat various bacterial infections, including pneumonia, sinusitis, skin infections, and urinary tract infections.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 7-14 days depending on the infection.
Elderly
No specific dose adjustment needed based on age alone, but renal function should be considered.
Renal_impairment
Dose adjustment required for creatinine clearance < 50 mL/min.
How to Take
Take orally with or without food, usually once daily. Do not take with antacids containing magnesium or aluminum, sucralfate, or iron supplements.
Mechanism of Action
Inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication, transcription, repair, and recombination.
Pharmacokinetics
Onset
Rapid onset, usually within 1-2 hours for antibacterial action.
Excretion
Primarily excreted unchanged in the urine, mainly by glomerular filtration and tubular secretion.
Half life
Approximately 6-8 hours.
Absorption
Rapid and almost complete oral absorption. Peak plasma concentrations usually attained within 1-2 hours.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to levofloxacin or other fluoroquinolones.
- •History of tendinitis or tendon rupture associated with fluoroquinolone use.
- •Patients with epilepsy.
- •Children and adolescents (due to risk of cartilage damage).
Drug Interactions
NSAIDs
Increased risk of CNS stimulation and convulsive seizures.
Warfarin
Increased anticoagulant effect.
Corticosteroids
Increased risk of tendon rupture.
Antacids (Mg/Al), Sucralfate, Iron/Zinc supplements
Decreased absorption of levofloxacin.
Antiarrhythmics (Class IA and III), Tricyclic antidepressants, Macrolides, Antipsychotics
Risk of QT prolongation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include CNS symptoms (confusion, hallucinations, tremors, convulsions), QT prolongation. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Should only be used if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, so caution is advised; discontinuation of nursing or the drug may be necessary.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA/DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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