Talmimax
Generic Name
Telmisartan
Manufacturer
ACI Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| talmimax 40 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Talmimax contains Telmisartan, an angiotensin II receptor blocker (ARB), used to treat high blood pressure and reduce cardiovascular risk.
Uses & Indications
Dosage
Adults
Usual starting dose is 40 mg once daily. Dose may be increased to a maximum of 80 mg once daily if needed.
Elderly
No dose adjustment is generally required for elderly patients.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. For severe impairment, caution is advised.
How to Take
Can be taken with or without food. Administer once daily at approximately the same time.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor, which inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect observed within 3 hours, full effect within 4-8 weeks.
Excretion
Excreted almost exclusively in feces via bile, mainly as unchanged drug.
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations reached in 0.5-1 hour. Absolute bioavailability is dose-dependent (approx. 42% for 40mg, 58% for 80mg).
Metabolism
Minimally metabolized; primarily conjugated to glucuronide.
Side Effects
Contraindications
- Hypersensitivity to Telmisartan or any excipient
- Pregnancy (especially 2nd and 3rd trimesters)
- Lactation
- Biliary obstructive disorders
- Severe hepatic impairment
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 ml/min/1.73m²)
Drug Interactions
Digoxin
Increased plasma digoxin levels.
Lithium
Increased serum lithium concentrations and toxicity.
Diuretics (e.g., Furosemide)
Increased risk of hypotension.
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce antihypertensive effect and increase risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension, dizziness, and tachycardia. Management involves supportive measures, gastric lavage, and symptomatic treatment. Hemodialysis is not effective.
Pregnancy & Lactation
Contraindicated during the 2nd and 3rd trimesters of pregnancy. Not recommended during the 1st trimester. Not recommended for use during lactation due to potential adverse effects on the infant.
Side Effects
Contraindications
- Hypersensitivity to Telmisartan or any excipient
- Pregnancy (especially 2nd and 3rd trimesters)
- Lactation
- Biliary obstructive disorders
- Severe hepatic impairment
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 ml/min/1.73m²)
Drug Interactions
Digoxin
Increased plasma digoxin levels.
Lithium
Increased serum lithium concentrations and toxicity.
Diuretics (e.g., Furosemide)
Increased risk of hypotension.
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce antihypertensive effect and increase risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension, dizziness, and tachycardia. Management involves supportive measures, gastric lavage, and symptomatic treatment. Hemodialysis is not effective.
Pregnancy & Lactation
Contraindicated during the 2nd and 3rd trimesters of pregnancy. Not recommended during the 1st trimester. Not recommended for use during lactation due to potential adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials like ONTARGET and TRANSCEND, demonstrating efficacy in hypertension and cardiovascular risk reduction.
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
- Renal function (BUN, creatinine)
- Blood pressure monitoring
Doctor Notes
- Advise patients to monitor blood pressure regularly. Counsel on lifestyle modifications. Caution in patients with volume depletion or severe congestive heart failure.
- Periodically assess renal function and serum electrolytes.
Patient Guidelines
- Take your medicine regularly as prescribed, even if you feel well.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue; use caution when driving or operating machinery until you know how Talmimax affects you.
Lifestyle Advice
- Adopt a healthy lifestyle including a balanced diet, regular exercise, and maintaining a healthy weight.
- Limit salt intake.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
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