Talopram
Generic Name
Talopram
Manufacturer
PharmaGenerics Inc.
Country
Global/Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| talopram 10 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Talopram 10 mg Tablet is a selective serotonin reuptake inhibitor (SSRI) used to treat depression and various anxiety disorders by restoring the balance of serotonin in the brain.
Uses & Indications
Dosage
Adults
Initial dose is usually 10 mg once daily, increased to a maximum of 20 mg daily after 1-2 weeks if needed. For certain indications, the maximum may be 30 mg.
Elderly
A lower initial dose, typically 5 mg once daily, is recommended. Maximum recommended dose usually 10 mg daily.
Renal_impairment
No dose adjustment is generally required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally, once daily, with or without food. Swallow the tablet whole with water. Do not chew or crush.
Mechanism of Action
Talopram selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission in the central nervous system.
Pharmacokinetics
Onset
Therapeutic effects may take 2-4 weeks to become fully apparent, though some patients may experience initial benefits sooner.
Excretion
Primarily excreted via urine (approximately 10% as unchanged drug) and feces.
Half life
Approximately 27-35 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, peak plasma concentrations typically achieved within 2-4 hours. Bioavailability is high, around 80%.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2C19. Active metabolites are formed but contribute minimally to overall effect.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping an MAOI
- Known hypersensitivity to talopram or any excipients
- Congenital long QT syndrome or known prolonged QT interval
- Concomitant use with other drugs that prolong the QT interval
Drug Interactions
MAOIs
Increased risk of serotonin syndrome.
NSAIDs, Aspirin, Warfarin
Increased risk of bleeding.
Drugs that prolong QT interval (e.g., Antiarrhythmics, Antipsychotics)
Increased risk of cardiac arrhythmias.
Other Serotonergic Drugs (e.g., Triptans, Tricyclic Antidepressants, Fentanyl, Lithium, Tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, nausea, vomiting, somnolence, tachycardia, and rarely, seizures or serotonin syndrome. Management involves symptomatic and supportive care, including maintaining an open airway, cardiac monitoring, and administration of activated charcoal if appropriate. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk. Consult your doctor.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping an MAOI
- Known hypersensitivity to talopram or any excipients
- Congenital long QT syndrome or known prolonged QT interval
- Concomitant use with other drugs that prolong the QT interval
Drug Interactions
MAOIs
Increased risk of serotonin syndrome.
NSAIDs, Aspirin, Warfarin
Increased risk of bleeding.
Drugs that prolong QT interval (e.g., Antiarrhythmics, Antipsychotics)
Increased risk of cardiac arrhythmias.
Other Serotonergic Drugs (e.g., Triptans, Tricyclic Antidepressants, Fentanyl, Lithium, Tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, nausea, vomiting, somnolence, tachycardia, and rarely, seizures or serotonin syndrome. Management involves symptomatic and supportive care, including maintaining an open airway, cardiac monitoring, and administration of activated charcoal if appropriate. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have been conducted to establish the efficacy and safety of Talopram in the treatment of major depressive disorder and various anxiety disorders, demonstrating its superior efficacy over placebo.
Lab Monitoring
- Baseline and periodic electrolyte monitoring (especially sodium) if hyponatremia is suspected.
- Liver function tests may be considered in patients with hepatic impairment or if symptoms suggest liver dysfunction.
- ECG may be considered for patients at risk of QT prolongation.
Doctor Notes
- Initiate treatment at the lowest effective dose and titrate slowly based on patient response and tolerability.
- Monitor for signs of suicidality, especially at the beginning of treatment and during dose changes.
- Educate patients about potential side effects and the importance of adherence.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as withdrawal symptoms may occur.
- It may take several weeks to feel the full benefits of the medicine.
- Avoid alcohol while taking Talopram.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.
Driving Precautions
Talopram may cause dizziness, drowsiness, or blurred vision. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Talopram therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Regular exercise and a balanced diet can complement the treatment.
- Practice stress-reduction techniques like meditation or yoga.
- Ensure adequate sleep.
- Maintain open communication with your healthcare provider.
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