Tamen
Generic Name
Tramadol Hydrochloride
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tamen 10 mg injection | ৳ 150.00 | N/A |
Description
Overview of the medicine
Tamen 10 mg Injection contains Tramadol Hydrochloride, an opioid analgesic used to relieve moderate to moderately severe pain. It works by binding to opioid receptors in the brain and spinal cord, altering the perception of pain.
Uses & Indications
Dosage
Adults
Typically, 50-100 mg by slow intravenous (IV) injection over 2-3 minutes, intramuscular (IM) injection, or subcutaneous (SC) injection every 4-6 hours as needed. Maximum daily dose usually 400 mg. For a 10 mg/mL vial, multiple vials might be required per dose.
Elderly
Reduced dosage may be required, especially in those over 75 years, usually 50 mg every 6 hours, not exceeding 300 mg daily. Dosage should be adjusted based on renal function.
Renal_impairment
Creatinine clearance < 30 mL/min: dosage interval should be extended to 12 hours, maximum daily dose not exceeding 200 mg.
How to Take
Administer by slow intravenous (IV) injection over 2-3 minutes, or as an infusion. Can also be given intramuscularly (IM) or subcutaneously (SC).
Mechanism of Action
Tramadol acts as a centrally acting synthetic opioid analgesic. It has a dual mechanism of action: it binds to μ-opioid receptors, and it also inhibits the reuptake of norepinephrine and serotonin, which contributes to its analgesic effect.
Pharmacokinetics
Onset
Within 15-30 minutes after intravenous administration.
Excretion
Mainly excreted by the kidneys (approximately 90%), with a small amount excreted in feces (approximately 10%).
Half life
Approximately 6-7 hours for the parent drug and 7.9 hours for the active metabolite O-desmethyltramadol (M1).
Absorption
Rapidly and almost completely absorbed after parenteral administration. Bioavailability is high.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4, to several metabolites including the active O-desmethyltramadol (M1).
Side Effects
Contraindications
- Acute intoxication with alcohol, hypnotics, analgesics, opioids, psychotropic drugs
- Patients receiving MAO inhibitors or who have taken them within the last 14 days
- Epilepsy not controlled by treatment
- Severe respiratory depression
Drug Interactions
Carbamazepine
Significantly decreases tramadol concentration, reducing analgesic effect.
MAO Inhibitors
Concomitant use is contraindicated due to risk of serotonin syndrome and seizures.
Serotonergic Drugs (e.g., SSRIs, SNRIs, TCAs)
Increased risk of serotonin syndrome.
CNS Depressants (e.g., benzodiazepines, alcohol, other opioids)
Increased risk of respiratory depression, profound sedation, coma, and death.
Storage
Store at room temperature (below 30°C), away from light and moisture. Do not freeze.
Overdose
Symptoms include respiratory depression, seizures, miosis, cardiovascular collapse, and coma. Treatment involves supportive measures, maintaining a patent airway, and administration of naloxone for opioid effects. Gastric lavage may be considered if recent oral ingestion (not applicable for injection directly).
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy, especially in the third trimester, due to risk of neonatal opioid withdrawal syndrome. Small amounts are excreted in breast milk; not recommended for nursing mothers.
Side Effects
Contraindications
- Acute intoxication with alcohol, hypnotics, analgesics, opioids, psychotropic drugs
- Patients receiving MAO inhibitors or who have taken them within the last 14 days
- Epilepsy not controlled by treatment
- Severe respiratory depression
Drug Interactions
Carbamazepine
Significantly decreases tramadol concentration, reducing analgesic effect.
MAO Inhibitors
Concomitant use is contraindicated due to risk of serotonin syndrome and seizures.
Serotonergic Drugs (e.g., SSRIs, SNRIs, TCAs)
Increased risk of serotonin syndrome.
CNS Depressants (e.g., benzodiazepines, alcohol, other opioids)
Increased risk of respiratory depression, profound sedation, coma, and death.
Storage
Store at room temperature (below 30°C), away from light and moisture. Do not freeze.
Overdose
Symptoms include respiratory depression, seizures, miosis, cardiovascular collapse, and coma. Treatment involves supportive measures, maintaining a patent airway, and administration of naloxone for opioid effects. Gastric lavage may be considered if recent oral ingestion (not applicable for injection directly).
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy, especially in the third trimester, due to risk of neonatal opioid withdrawal syndrome. Small amounts are excreted in breast milk; not recommended for nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of tramadol for various pain conditions. Ongoing research continues to evaluate its role in pain management and potential new indications.
Lab Monitoring
- Renal function tests (for dose adjustment)
- Liver function tests (baseline and if clinically indicated)
- Monitoring for respiratory depression, sedation, and seizure risk
Doctor Notes
- Careful patient selection and ongoing monitoring for signs of abuse, misuse, and addiction are crucial.
- Consider lower initial doses and slower titration in opioid-naïve patients and those with risk factors for respiratory depression.
- Educate patients on safe use, storage, and disposal of opioids.
Patient Guidelines
- Do not exceed the prescribed dose.
- Do not drive or operate heavy machinery until you know how this medicine affects you.
- Inform your doctor about all other medications you are taking.
- Report any unusual or severe side effects immediately.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Tramadol can cause dizziness, drowsiness, and impaired mental and physical abilities. Patients should be warned not to drive or operate hazardous machinery until they are reasonably certain that the drug does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Avoid alcohol consumption.
- Engage in gentle exercise if possible (e.g., walking) to help with pain management.
- Maintain a balanced diet to support overall health.
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