Tamsulin
Generic Name
tamsulin-04-mg-capsule
Manufacturer
Example Manufacturer (e.g., Square Pharmaceuticals Ltd.)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tamsulin 04 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Tamsulosin 0.4 mg capsule is an alpha-blocker used to treat symptoms of an enlarged prostate (benign prostatic hyperplasia or BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
Uses & Indications
Dosage
Adults
0.4 mg once daily, taken approximately 30 minutes after the same meal each day. The capsule should be swallowed whole and not crushed, chewed, or opened.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with mild to moderate renal impairment. Caution is advised in severe renal impairment (CrCl < 10 mL/min) as such patients have not been studied.
How to Take
Take orally, once daily, approximately 30 minutes after the same meal each day. Swallow the capsule whole with a glass of water. Do not chew, crush, or open the capsule.
Mechanism of Action
Tamsulosin selectively blocks alpha-1A adrenergic receptors primarily located in the prostate, bladder neck, and urethra. This blockade causes relaxation of the smooth muscles in these tissues, leading to a decrease in bladder outlet obstruction and improved urine flow.
Pharmacokinetics
Onset
Symptomatic improvement may be observed within 2-4 weeks, though some effects can be seen earlier.
Excretion
Mainly excreted in the urine (76%) as metabolites, with a small amount excreted in feces (21%).
Half life
Approximately 9-15 hours (terminal half-life).
Absorption
Well absorbed from the gastrointestinal tract, with approximately 90% bioavailability. Absorption is affected by food.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2D6.
Side Effects
Contraindications
- •Hypersensitivity to tamsulosin hydrochloride or any component of the formulation
- •History of orthostatic hypotension
- •Severe hepatic insufficiency
Drug Interactions
Strong CYP2D6 inhibitors (e.g., paroxetine)
Coadministration can also increase tamsulosin exposure, similar to CYP3A4 inhibitors.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
Increased risk of symptomatic hypotension due to potential additive vasodilatory effects. Use with caution.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
Coadministration with strong CYP3A4 inhibitors can significantly increase tamsulosin exposure. Consider dosage reduction or discontinuation.
Other alpha-1 blockers (e.g., doxazosin, prazosin)
Increased risk of hypotensive effects due to additive pharmacodynamic effects.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose with tamsulosin can lead to severe hypotensive effects. Management involves supportive measures, including lying the patient down, administering IV fluids, and if necessary, vasopressors. Monitor vital signs and renal function.
Pregnancy & Lactation
Tamsulosin is not indicated for use in women and has not been evaluated in pregnant or lactating women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, refer to product packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent, generic versions available
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Global Brand Names
International brand names for this medicine
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