Tamurin
Generic Name
Tamsulosin 0.4 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tamurin 04 mg capsule | ৳ 8.00 | ৳ 32.00 |
Description
Overview of the medicine
Tamurin 0.4 mg Capsule contains Tamsulosin, an alpha-blocker used to treat the symptoms of benign prostatic hyperplasia (BPH) in men. It helps to relax the muscles in the prostate and bladder neck, making it easier to urinate.
Uses & Indications
Dosage
Adults
0.4 mg orally once daily, approximately 30 minutes after the same meal each day.
Elderly
No specific dose adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take orally, once daily, approximately 30 minutes after the same meal each day. Swallow the capsule whole; do not crush, chew, or open.
Mechanism of Action
Tamsulosin selectively blocks alpha-1A and alpha-1D adrenergic receptors in the prostate, prostatic capsule, bladder neck, and prostatic urethra. This blockade causes relaxation of the smooth muscles in these areas, leading to an improvement in urine flow rate and reduction in BPH symptoms.
Pharmacokinetics
Onset
Clinical improvement often seen within 1-2 weeks, full effect in 2-4 weeks.
Excretion
Mainly excreted in urine, primarily as metabolites.
Half life
Approximately 9-15 hours.
Absorption
Well absorbed from the gastrointestinal tract, nearly 90%.
Metabolism
Extensively metabolized by cytochrome P450 enzymes in the liver, primarily CYP3A4 and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to Tamsulosin or any component of the formulation
- History of orthostatic hypotension
- Severe hepatic impairment
Drug Interactions
Other alpha-adrenergic blocking agents
Concomitant use may lead to additive hypotensive effects.
Strong CYP2D6 inhibitors (e.g., Paroxetine)
May increase Tamsulosin exposure.
PDE5 inhibitors (e.g., Sildenafil, Tadalafil)
Concomitant use may lead to additive hypotensive effects.
Strong CYP3A4 inhibitors (e.g., Ketoconazole)
May increase Tamsulosin exposure, leading to increased risk of hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypotensive effects. Management includes supportive measures, such as lying down the patient and, if necessary, administering vasopressors and/or intravenous fluids. Blood pressure and heart rate should be monitored.
Pregnancy & Lactation
Tamurin is not indicated for use in women. Safety in pregnancy and lactation has not been established.
Side Effects
Contraindications
- Hypersensitivity to Tamsulosin or any component of the formulation
- History of orthostatic hypotension
- Severe hepatic impairment
Drug Interactions
Other alpha-adrenergic blocking agents
Concomitant use may lead to additive hypotensive effects.
Strong CYP2D6 inhibitors (e.g., Paroxetine)
May increase Tamsulosin exposure.
PDE5 inhibitors (e.g., Sildenafil, Tadalafil)
Concomitant use may lead to additive hypotensive effects.
Strong CYP3A4 inhibitors (e.g., Ketoconazole)
May increase Tamsulosin exposure, leading to increased risk of hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypotensive effects. Management includes supportive measures, such as lying down the patient and, if necessary, administering vasopressors and/or intravenous fluids. Blood pressure and heart rate should be monitored.
Pregnancy & Lactation
Tamurin is not indicated for use in women. Safety in pregnancy and lactation has not been established.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated Tamsulosin's efficacy and safety in improving LUTS associated with BPH.
Lab Monitoring
- Regular monitoring of blood pressure, especially after the first dose or dose titration.
Doctor Notes
- Counsel patients about orthostatic hypotension and to avoid situations where injury could result from syncope.
- Advise patients considering cataract surgery to inform their ophthalmologist about Tamsulosin use.
Patient Guidelines
- Take as directed by your doctor.
- Do not crush, chew, or open the capsule.
- Be aware of potential dizziness or lightheadedness, especially when standing up quickly.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or lightheadedness, especially at the start of treatment. Patients should be warned about driving or operating machinery until they know how Tamurin affects them.
Lifestyle Advice
- Avoid sudden changes in posture to minimize dizziness.
- Inform your doctor if you have eye surgery scheduled, as it may affect cataract surgery (Intraoperative Floppy Iris Syndrome).
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.