Tapisis
Generic Name
Tapinarof 1% Cream
Manufacturer
Dermavant Sciences
Country
United States
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tapisis 1 cream | ৳ 1,000.00 | N/A |
Description
Overview of the medicine
Tapisis-1-Cream (Tapinarof 1% Cream) is a topical medication used for the treatment of plaque psoriasis in adults. It works by targeting the aryl hydrocarbon receptor (AhR) to reduce inflammation and normalize skin cell growth.
Uses & Indications
Dosage
Adults
Apply a thin layer to affected areas once daily. Wash hands after application.
Elderly
No specific dose adjustment required.
Renal_impairment
No specific dose adjustment required as systemic absorption is minimal.
How to Take
For topical use only. Apply to affected skin areas. Avoid application to eyes, mouth, or vagina. Do not wrap or bandage the treated area unless directed by a doctor.
Mechanism of Action
Tapinarof is an aryl hydrocarbon receptor (AhR) agonist. Activation of AhR regulates various cellular processes, including inflammation and skin barrier function. In psoriasis, AhR activation by tapinarof helps to reduce pro-inflammatory cytokines, decrease epidermal proliferation, and promote skin barrier restoration.
Pharmacokinetics
Onset
Clinical improvement typically seen within 4-8 weeks.
Excretion
Primarily fecal, with some renal excretion.
Half life
Approximately 18.9 hours (plasma).
Absorption
Systemic absorption is minimal following topical application.
Metabolism
Extensively metabolized primarily via oxidation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to tapinarof or any component of the cream.
Drug Interactions
Storage
Store at room temperature (20°C to 25°C). Do not freeze. Keep out of reach of children. Keep the tube tightly closed.
Overdose
Overdose with topical application is unlikely due to minimal systemic absorption. In case of accidental ingestion, seek medical advice.
Pregnancy & Lactation
Use in pregnancy only if potential benefit justifies potential risk to the fetus. Caution advised during lactation; systemic absorption is minimal, but risks to nursing infant are unknown.
Side Effects
Contraindications
- Hypersensitivity to tapinarof or any component of the cream.
Drug Interactions
Storage
Store at room temperature (20°C to 25°C). Do not freeze. Keep out of reach of children. Keep the tube tightly closed.
Overdose
Overdose with topical application is unlikely due to minimal systemic absorption. In case of accidental ingestion, seek medical advice.
Pregnancy & Lactation
Use in pregnancy only if potential benefit justifies potential risk to the fetus. Caution advised during lactation; systemic absorption is minimal, but risks to nursing infant are unknown.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Refer to product label for specific shelf life (typically 24 months from manufacturing).
Availability
Pharmacies
Approval Status
FDA Approved
Patent Status
Patented (currently under patent protection)
Clinical Trials
Tapinarof 1% cream was evaluated in two phase 3 clinical trials (PSOARING 1 and PSOARING 2) involving adult patients with mild to severe plaque psoriasis, demonstrating significant efficacy and good safety profile.
Lab Monitoring
- No specific routine lab monitoring required.
Doctor Notes
- Educate patients on proper application technique and potential localized adverse reactions.
- Assess patient's psoriasis severity and extent before initiating treatment.
- Monitor for signs of skin irritation, folliculitis, or infection during treatment.
- Advise patients that full therapeutic effects may take several weeks.
Patient Guidelines
- Apply only to skin affected by psoriasis.
- Wash hands thoroughly after application.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Do not use on open wounds or infected skin.
- Report any severe skin irritation or adverse reactions to your doctor.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not apply extra cream to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid irritants that can worsen psoriasis.
- Follow doctor's advice regarding sun exposure.
- Moisturize skin regularly as advised by your doctor.
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Global Brand Names
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