Taspia
Generic Name
Tamsulosin Hydrochloride 0.4 mg Extended-Release Capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| taspia 04 mg capsule | ৳ 10.00 | ৳ 60.00 |
Description
Overview of the medicine
Tamsulosin Hydrochloride is an alpha-1 blocker used to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia or BPH). It helps to relax the muscles in the prostate and bladder neck, making it easier to urinate.
Uses & Indications
Dosage
Adults
0.4 mg once daily, administered approximately 30 minutes after the same meal each day. May be increased to 0.8 mg once daily after 2 to 4 weeks if necessary.
Elderly
No dosage adjustment required for elderly patients.
Renal_impairment
No dosage adjustment required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment (CrCl < 10 mL/min) as it has not been studied.
How to Take
Take one capsule orally once daily, approximately 30 minutes after the same meal each day. Do not crush, chew, or open the capsule.
Mechanism of Action
Tamsulosin selectively blocks alpha-1A and alpha-1D adrenergic receptors in the prostate, prostatic capsule, bladder neck, and prostatic urethra. Blockage of these receptors leads to relaxation of the smooth muscle in these tissues, thereby improving urine flow and reducing symptoms of BPH.
Pharmacokinetics
Onset
Improvement in urinary flow may be seen within 4 to 8 hours, but symptomatic relief may take 1 to 2 weeks.
Excretion
Primarily excreted in the urine (76% as metabolites, 4-9% unchanged drug) and feces (21% as metabolites).
Half life
Approximately 9-15 hours in plasma.
Absorption
Well absorbed from the gastrointestinal tract, nearly 90% bioavailable under fasting conditions. Food reduces absorption by 30% but increases consistency.
Metabolism
Extensively metabolized by cytochrome P450 enzymes in the liver (primarily CYP3A4 and CYP2D6).
Side Effects
Contraindications
- Hypersensitivity to Tamsulosin Hydrochloride or any component of the formulation
- History of orthostatic hypotension
Drug Interactions
Warfarin
Caution is advised as Tamsulosin may increase Warfarin's anticoagulant effect.
Other alpha-adrenergic blocking agents
Increased risk of hypotension. Concomitant use is not recommended.
Strong CYP2D6 inhibitors (e.g., Paroxetine)
May significantly increase Tamsulosin exposure. Use with caution.
PDE5 inhibitors (e.g., Sildenafil, Tadalafil)
Increased risk of hypotension. Use with caution.
Strong CYP3A4 inhibitors (e.g., Ketoconazole)
May significantly increase Tamsulosin exposure. Use with caution, consider dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypotension. Support blood pressure and heart rate with intravenous fluids and vasopressors as needed. Monitor for adverse effects.
Pregnancy & Lactation
Tamsulosin is not indicated for use in women. Safety in pregnancy and lactation has not been established.
Side Effects
Contraindications
- Hypersensitivity to Tamsulosin Hydrochloride or any component of the formulation
- History of orthostatic hypotension
Drug Interactions
Warfarin
Caution is advised as Tamsulosin may increase Warfarin's anticoagulant effect.
Other alpha-adrenergic blocking agents
Increased risk of hypotension. Concomitant use is not recommended.
Strong CYP2D6 inhibitors (e.g., Paroxetine)
May significantly increase Tamsulosin exposure. Use with caution.
PDE5 inhibitors (e.g., Sildenafil, Tadalafil)
Increased risk of hypotension. Use with caution.
Strong CYP3A4 inhibitors (e.g., Ketoconazole)
May significantly increase Tamsulosin exposure. Use with caution, consider dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypotension. Support blood pressure and heart rate with intravenous fluids and vasopressors as needed. Monitor for adverse effects.
Pregnancy & Lactation
Tamsulosin is not indicated for use in women. Safety in pregnancy and lactation has not been established.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have demonstrated Tamsulosin's efficacy and safety in improving BPH symptoms. Data available from phase III trials.
Lab Monitoring
- Regular monitoring of blood pressure, especially after the first dose or dose increase.
- Consider PSA monitoring for prostate cancer screening before starting therapy and periodically thereafter.
Doctor Notes
- Advise patients about the potential for orthostatic hypotension, especially with the first dose or dose titration.
- Counsel patients on the importance of taking the medication consistently after the same meal.
- Remind patients to inform their ophthalmologist about Tamsulosin use before cataract or glaucoma surgery.
Patient Guidelines
- Take the capsule whole; do not crush, chew, or open it.
- Take it approximately 30 minutes after the same meal each day.
- Be aware of potential dizziness, especially when standing up from a sitting or lying position.
- Inform your doctor if you are undergoing cataract or glaucoma surgery, as this medicine can cause Intraoperative Floppy Iris Syndrome (IFIS).
Missed Dose Advice
If a dose is missed, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses at once.
Driving Precautions
This medicine may cause dizziness, lightheadedness, or fainting, especially at the start of treatment or when changing dosage. Avoid driving or operating machinery until you know how Tamsulosin affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid excessive alcohol consumption.
- Stay hydrated by drinking plenty of water.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.