Tasti
Generic Name
Deflazacort
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tasti 6 mg tablet | ৳ 2.51 | ৳ 25.10 |
Description
Overview of the medicine
Tasti 6 mg Tablet contains Deflazacort, a corticosteroid used to treat various inflammatory and autoimmune conditions, as well as Duchenne muscular dystrophy.
Uses & Indications
Dosage
Adults
Initial dosage for adults typically ranges from 6 mg to 90 mg daily, adjusted based on individual response and condition severity. Should be taken once daily.
Elderly
Similar to adult dosage, but caution advised due to potential comorbidities and increased risk of adverse effects.
Renal_impairment
No specific dose adjustment is generally required, but close monitoring is recommended.
How to Take
Take orally, with or without food, usually once daily. It can be taken with food to minimize gastrointestinal upset.
Mechanism of Action
Deflazacort acts as a glucocorticoid receptor agonist. It exerts its anti-inflammatory and immunosuppressive effects by binding to specific glucocorticoid receptors, modulating gene expression and reducing the production of inflammatory mediators.
Pharmacokinetics
Onset
Varies depending on the condition being treated, but generally within a few hours for initial effects.
Excretion
Primarily excreted in the urine (approximately 70%) and feces (approximately 30%), mainly as inactive metabolites.
Half life
The active metabolite has a plasma half-life of approximately 1.1 to 1.9 hours.
Absorption
Well absorbed orally. Peak plasma concentration of the active metabolite (21-des-deflazacort) is reached within 1.5-2 hours.
Metabolism
Rapidly metabolized in the liver to its primary active metabolite, 21-des-deflazacort.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines
Drug Interactions
Anticoagulants (e.g., Warfarin)
Deflazacort may enhance or diminish the effect of anticoagulants; close monitoring of INR is required.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin)
May decrease deflazacort plasma levels, reducing its effectiveness.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase deflazacort plasma levels, potentially increasing side effects.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Chronic overdose may lead to adrenal suppression and Cushingoid features.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; advise caution during lactation.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines
Drug Interactions
Anticoagulants (e.g., Warfarin)
Deflazacort may enhance or diminish the effect of anticoagulants; close monitoring of INR is required.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin)
May decrease deflazacort plasma levels, reducing its effectiveness.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase deflazacort plasma levels, potentially increasing side effects.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Chronic overdose may lead to adrenal suppression and Cushingoid features.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; advise caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
DGDA Approved
Patent Status
Off-patent
Clinical Trials
Deflazacort has been extensively studied in clinical trials for its efficacy and safety in various inflammatory, autoimmune conditions, and particularly for Duchenne Muscular Dystrophy.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels
- Bone mineral density (for long-term use)
- Adrenal function tests
- Blood pressure monitoring
Doctor Notes
- Monitor patients for signs of adrenal suppression, especially after prolonged therapy or dose reduction.
- Regularly assess bone mineral density, blood glucose, and electrolyte levels.
- Educate patients on potential side effects and the importance of not discontinuing the drug abruptly.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to withdrawal symptoms.
- Take the tablet whole with a glass of water.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any unusual side effects or worsening of symptoms to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Deflazacort may cause dizziness or visual disturbances in some individuals. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health, especially with long-term use.
- Engage in regular, moderate exercise if possible.
- Avoid exposure to people with infections, especially chickenpox or measles, as corticosteroids can weaken the immune system.
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Global Brand Names
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