Taxetil-DS
Generic Name
Cefpodoxime Proxetil
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| taxetil ds 80 mg suspension | ৳ 175.00 | N/A |
Description
Overview of the medicine
Cefpodoxime proxetil is an oral third-generation cephalosporin antibiotic. It is a prodrug that is hydrolyzed to cefpodoxime in vivo. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Not typically used for adults at this strength; adult dosage for Cefpodoxime is typically 100-200 mg every 12 hours for tablet forms. If used for adults, dose would be adjusted.
Elderly
No specific dose adjustment necessary unless severe renal impairment. Refer to adult dosage guidelines with caution for elderly with normal renal function.
Renal_impairment
Adjust dose for creatinine clearance < 30 mL/min; administer every 24 hours. For children, consult a physician.
How to Take
Shake the bottle well before each use. Administer orally using the provided measuring spoon or dropper. It should be taken with food to enhance absorption.
Mechanism of Action
Cefpodoxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Primarily excreted unchanged in the urine, with about 29-33% of the administered dose recovered in the urine within 12 hours.
Half life
Approximately 2.0-3.0 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 50% and increases with food.
Metabolism
Cefpodoxime proxetil is a prodrug that is hydrolyzed by esterases in the gut wall to the active metabolite cefpodoxime.
Side Effects
Contraindications
- Hypersensitivity to cefpodoxime, other cephalosporins, or any component of the formulation
- History of anaphylactic reactions to penicillin
Drug Interactions
Probenecid
May increase cefpodoxime levels.
Nephrotoxic drugs (e.g., aminoglycosides)
May increase risk of nephrotoxicity (though less common with cefpodoxime).
Antacids/H2 blockers/Proton Pump Inhibitors
May decrease absorption of cefpodoxime.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard after 10 days.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management is primarily supportive and symptomatic. Hemodialysis can remove cefpodoxime from the system.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefpodoxime, other cephalosporins, or any component of the formulation
- History of anaphylactic reactions to penicillin
Drug Interactions
Probenecid
May increase cefpodoxime levels.
Nephrotoxic drugs (e.g., aminoglycosides)
May increase risk of nephrotoxicity (though less common with cefpodoxime).
Antacids/H2 blockers/Proton Pump Inhibitors
May decrease absorption of cefpodoxime.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard after 10 days.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management is primarily supportive and symptomatic. Hemodialysis can remove cefpodoxime from the system.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years for dry powder, 10 days after reconstitution when stored in refrigerator.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic (Patent Expired)
Clinical Trials
Numerous clinical trials have established the efficacy and safety of cefpodoxime proxetil in treating various bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (for prolonged therapy)
- Liver function tests (rarely needed, but in case of suspected hepatotoxicity)
Doctor Notes
- Educate parents/caregivers on proper reconstitution and administration of the suspension.
- Emphasize completion of the full course to prevent resistance.
- Monitor for signs of allergic reactions, especially in penicillin-allergic patients (cross-reactivity possible).
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Do not save medication for future infections.
- Report any severe or persistent side effects to your doctor.
- Shake suspension well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Cefpodoxime may cause dizziness in some patients. Patients should be advised to exercise caution before driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment (can worsen side effects).
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.