Tdcef-DS
Generic Name
Cefixime 200 mg Dry Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tdcef ds 200 mg suspension | ৳ 300.00 | N/A |
Description
Overview of the medicine
Tdcef-DS 200 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic. It is primarily used to treat a wide range of bacterial infections including those affecting the respiratory tract, urinary tract, and ears. This suspension form is particularly suitable for pediatric patients.
Uses & Indications
Dosage
Adults
Not typically recommended for adults in suspension form; usually 200-400 mg daily as tablet/capsule.
Elderly
Dosage adjustment may not be necessary unless severe renal impairment.
Children
8 mg/kg/day orally, as a single dose or in two divided doses for 7-14 days. Maximum 400 mg/day.
Renal_impairment
Dosage adjustment required for creatinine clearance < 60 mL/min.
How to Take
For oral administration. The dry powder should be reconstituted with boiled and cooled water as per instructions on the label. Shake well before each use. Can be taken with or without food.
Mechanism of Action
Cefixime exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. This leads to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations usually occur within 2-6 hours after oral administration.
Excretion
Renal excretion (about 50% of absorbed dose), some biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed, food may delay but not significantly alter absorption. Peak plasma concentrations usually occur within 2-6 hours.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase the anticoagulant effect, requiring close monitoring of INR.
Carbamazepine
May increase carbamazepine plasma levels.
Oral Contraceptives
Theoretical risk of reduced efficacy of oral contraceptives (though less commonly observed).
Storage
Store dry powder below 30°C in a dry place, away from direct sunlight and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period (e.g., 7 or 14 days).
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be supportive and symptomatic. Hemodialysis and peritoneal dialysis do not remove significant quantities of cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, it should be used during pregnancy only if clearly needed. Cefixime is excreted in human milk in small quantities; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase the anticoagulant effect, requiring close monitoring of INR.
Carbamazepine
May increase carbamazepine plasma levels.
Oral Contraceptives
Theoretical risk of reduced efficacy of oral contraceptives (though less commonly observed).
Storage
Store dry powder below 30°C in a dry place, away from direct sunlight and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period (e.g., 7 or 14 days).
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be supportive and symptomatic. Hemodialysis and peritoneal dialysis do not remove significant quantities of cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, it should be used during pregnancy only if clearly needed. Cefixime is excreted in human milk in small quantities; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months for unopened dry powder. 7-14 days after reconstitution when stored in a refrigerator (2-8°C).
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections, including acute otitis media, pharyngitis, tonsillitis, and uncomplicated urinary tract infections. Studies have shown high cure rates and good tolerability.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) should be monitored in patients with pre-existing renal impairment and during prolonged therapy.
- Complete blood count (CBC) during prolonged use.
- Liver function tests if clinically indicated.
Doctor Notes
- Counsel patients/parents on the importance of completing the full course of antibiotics to prevent resistance and recurrence.
- Instruct on proper reconstitution of the dry powder and storage of the mixed suspension.
- Be aware of potential for *C. difficile* infection, especially in prolonged therapy.
Patient Guidelines
- Complete the entire prescribed course of medication, even if symptoms improve.
- Shake the suspension well before each dose.
- Follow instructions for reconstitution and storage, usually refrigeration is required after mixing.
- Do not use after the expiry date or if the solution changes color or contains particles.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid self-medication with antibiotics for viral infections.
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