Tekna
Generic Name
Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tekna 100 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Tekna (Paracetamol) is a widely used over-the-counter medication for the relief of mild to moderate pain and fever. It belongs to the class of non-opioid analgesics and antipyretics.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg every 4-6 hours as needed. Maximum 4000 mg in 24 hours.
Elderly
Usually the same as adults, but caution for renal/hepatic impairment.
Renal_impairment
Dosage adjustment may be required; consult a physician. Extended dosing interval for severe impairment.
How to Take
Take orally with or without food. Do not exceed the recommended dose.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system, increasing the pain threshold by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in prostaglandin synthesis. Its antipyretic effect is due to direct action on the heat-regulating centers in the hypothalamus, leading to peripheral vasodilation and sweating.
Pharmacokinetics
Onset
10 to 30 minutes (analgesia), 30 to 60 minutes (antipyresis)
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1 to 3 hours, increased in hepatic impairment and overdose.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 10 to 60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 to a toxic intermediate, NAPQI, which is normally detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of liver damage.
Warfarin
May increase anticoagulant effect.
Isoniazid, Rifampin
May increase hepatotoxicity.
Phenytoin, Carbamazepine
Increased metabolism of paracetamol.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) administration.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of liver damage.
Warfarin
May increase anticoagulant effect.
Isoniazid, Rifampin
May increase hepatotoxicity.
Phenytoin, Carbamazepine
Increased metabolism of paracetamol.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) administration.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Available in pharmacies and retail stores nationwide
Approval Status
Approved by DGDA and international health authorities
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Paracetamol has been extensively studied in numerous clinical trials establishing its efficacy and safety for pain and fever relief.
Lab Monitoring
- Liver function tests (in cases of prolonged use or suspected overdose)
- Renal function tests (in patients with pre-existing renal impairment)
Doctor Notes
- Advise patients on maximum daily dose and to avoid concurrent use with other paracetamol-containing products.
- Caution in patients with hepatic impairment, severe renal impairment, and chronic alcohol users.
- Monitor liver function tests in long-term users or in cases of suspected overdose.
Patient Guidelines
- Do not exceed the maximum daily dose.
- Avoid concurrent use with other paracetamol-containing products.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tekna (Paracetamol) generally does not impair ability to drive or operate machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Get sufficient rest for recovery from illness.
- Avoid alcohol consumption during treatment.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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