Telcardis Plus
Generic Name
Telmisartan 80 mg & Hydrochlorothiazide 12.5 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telcardis plus 80 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Telcardis Plus 80 mg Tablet is a combination medicine used to treat high blood pressure (hypertension). It contains Telmisartan, an angiotensin receptor blocker (ARB), and Hydrochlorothiazide, a thiazide diuretic. This combination helps to lower blood pressure more effectively than either component alone, reducing the risk of cardiovascular events.
Uses & Indications
Dosage
Adults
Usually one tablet (Telmisartan 80 mg / Hydrochlorothiazide 12.5 mg) orally once daily.
Elderly
No dosage adjustment is generally required, but close monitoring is advised due to potential for renal impairment.
Renal_impairment
Not recommended for patients with severe renal impairment (creatinine clearance < 30 mL/min). Dose adjustment may be necessary in moderate impairment.
How to Take
Take the tablet orally once daily, with or without food, at approximately the same time each day.
Mechanism of Action
Telmisartan blocks the action of angiotensin II, a substance in the body that constricts blood vessels, thereby relaxing blood vessels and lowering blood pressure. Hydrochlorothiazide is a diuretic that increases the excretion of sodium and water from the body through urine, which also helps to lower blood pressure.
Pharmacokinetics
Onset
Telmisartan: Within 3 hours. Hydrochlorothiazide: Within 2 hours.
Excretion
Telmisartan: Primarily excreted unchanged in feces (97%). Hydrochlorothiazide: Primarily excreted unchanged in urine.
Half life
Telmisartan: Approximately 24 hours. Hydrochlorothiazide: 5.6 to 14.8 hours.
Absorption
Telmisartan: Well absorbed, bioavailability 42-58%. Hydrochlorothiazide: Well absorbed, bioavailability 65-75%.
Metabolism
Telmisartan: Conjugated to form an acylglucuronide. Hydrochlorothiazide: Not extensively metabolized.
Side Effects
Contraindications
- Hypersensitivity to telmisartan, hydrochlorothiazide, or any sulfonamide-derived drugs.
- Pregnancy (second and third trimesters).
- Severe hepatic or renal impairment (creatinine clearance < 30 mL/min).
- Anuria.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment.
Drug Interactions
NSAIDs
Reduced antihypertensive effect, potential for worsening renal function.
Digoxin
Increased digoxin levels and toxicity due to hydrochlorothiazide-induced hypokalemia.
Lithium
Increased serum lithium concentrations and lithium toxicity.
Other antihypertensives
Additive hypotensive effect.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypotension, dizziness, tachycardia, bradycardia (due to telmisartan), and electrolyte depletion (due to hydrochlorothiazide). Treatment is symptomatic and supportive. Induce emesis or perform gastric lavage if ingestion is recent. Administer activated charcoal.
Pregnancy & Lactation
Category D for Telmisartan (second and third trimesters), contraindicated during pregnancy due to fetal toxicity. Not recommended during breastfeeding as it may pass into breast milk and potentially harm the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Generics available (off-patent)
WHO Essential Medicine
YesClinical Trials
Clinical trials have demonstrated the efficacy and safety of Telmisartan/Hydrochlorothiazide combination in reducing blood pressure and improving cardiovascular outcomes in patients with hypertension.
Lab Monitoring
- Blood pressure monitoring
- Serum electrolytes (potassium, sodium, magnesium, calcium)
- Renal function (creatinine, BUN)
- Liver function tests
- Uric acid levels
Doctor Notes
- Emphasize regular blood pressure and electrolyte monitoring.
- Counsel patients on potential for dizziness and importance of adherence.
- Review patient's medication list for potential drug interactions, especially NSAIDs and potassium supplements.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or lightheadedness, especially at the beginning of treatment or when changing dosage. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid smoking and limit alcohol consumption.
- Monitor your blood pressure regularly at home.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.