Telmipres
Generic Name
Telmisartan
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telmipres 80 mg tablet | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Telmipres 80 mg Tablet contains Telmisartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events like heart attack and stroke in patients at high risk.
Uses & Indications
Dosage
Adults
The usual recommended dose is 40 mg once daily. For some patients, 80 mg once daily may be appropriate. Max daily dose is 80 mg.
Elderly
No dose adjustment is necessary for elderly patients.
Renal_impairment
No dose adjustment is required for patients with mild to moderate renal impairment. Caution is advised in severe renal impairment and regular monitoring of potassium levels is recommended.
How to Take
Telmipres 80 mg Tablet should be taken orally once daily with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues (e.g., vascular smooth muscle, adrenal gland). This inhibition prevents angiotensin II's vasoconstrictor and aldosterone-secreting effects, leading to a reduction in blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect begins within 3 hours; maximum effect achieved within 4-8 weeks.
Excretion
Almost exclusively excreted in feces via biliary elimination, with less than 1% excreted in urine.
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 42-58%. Food intake has a minor effect on absorption.
Metabolism
Metabolized by conjugation to form an acylglucuronide, which is pharmacologically inactive.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Pregnancy (second and third trimesters).
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Digoxin
Increased plasma concentrations of digoxin have been reported when Telmisartan was co-administered. Monitor digoxin levels.
Lithium
Reversible increases in serum lithium concentrations and toxicity have been reported. Monitor serum lithium levels.
Diuretics and other antihypertensive agents
May enhance the hypotensive effect of Telmisartan.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
May reduce the antihypertensive effect of Telmisartan and increase the risk of renal impairment, especially in dehydrated or elderly patients.
Potassium-sparing diuretics or potassium supplements
May lead to hyperkalemia. Monitor serum potassium levels.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data are available on overdose in humans. The most likely manifestations of overdose are hypotension and tachycardia; bradycardia might also occur. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Telmisartan is contraindicated during the second and third trimesters of pregnancy due to fetal toxicity. It is not recommended during the first trimester. Due to the potential for adverse effects on the nursing infant, it is advised to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Pregnancy (second and third trimesters).
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Digoxin
Increased plasma concentrations of digoxin have been reported when Telmisartan was co-administered. Monitor digoxin levels.
Lithium
Reversible increases in serum lithium concentrations and toxicity have been reported. Monitor serum lithium levels.
Diuretics and other antihypertensive agents
May enhance the hypotensive effect of Telmisartan.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
May reduce the antihypertensive effect of Telmisartan and increase the risk of renal impairment, especially in dehydrated or elderly patients.
Potassium-sparing diuretics or potassium supplements
May lead to hyperkalemia. Monitor serum potassium levels.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data are available on overdose in humans. The most likely manifestations of overdose are hypotension and tachycardia; bradycardia might also occur. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Telmisartan is contraindicated during the second and third trimesters of pregnancy due to fetal toxicity. It is not recommended during the first trimester. Due to the potential for adverse effects on the nursing infant, it is advised to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (e.g., US FDA, DGDA)
Patent Status
Off-patent
Clinical Trials
Telmisartan has been extensively studied in large clinical trials (e.g., ONTARGET, TRANSCEND) demonstrating its efficacy in reducing cardiovascular events in high-risk patients and its role in managing hypertension.
Lab Monitoring
- Serum electrolytes (especially potassium levels), particularly in patients with renal impairment or those on potassium-sparing diuretics.
- Renal function (serum creatinine, BUN) periodically, especially in patients with pre-existing renal disease.
- Liver function tests in patients with hepatic impairment.
Doctor Notes
- Counsel patients on the importance of consistent dosing and adherence.
- Monitor blood pressure, renal function, and serum potassium regularly.
- Advise patients to report any symptoms of angioedema immediately.
- Caution about use in pregnancy; discontinue immediately if pregnancy is detected.
Patient Guidelines
- Take Telmipres 80 mg Tablet exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor, even if you feel well.
- Inform your doctor if you experience any swelling of the face, lips, tongue, or throat (angioedema).
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Telmipres 80 mg Tablet may cause dizziness or drowsiness in some individuals. Patients should be cautioned about operating machinery or driving until they know how they react to the medication.
Lifestyle Advice
- Adopt a healthy lifestyle including a balanced diet low in sodium.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption.
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