Telmivas
Generic Name
Telmisartan + Amlodipine
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telmivas 20 mg tablet | ৳ 10.50 | ৳ 105.00 |
| telmivas 40 mg tablet | ৳ 12.50 | ৳ 125.00 |
| telmivas 80 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Telmivas is a combination medication used to treat high blood pressure (hypertension). It contains Telmisartan, an Angiotensin II Receptor Blocker (ARB), and Amlodipine, a Calcium Channel Blocker (CCB). These two medications work together to relax blood vessels, allowing blood to flow more easily and thereby lowering blood pressure.
Uses & Indications
Dosage
Adults
Typically, one Telmivas 40 mg + 5 mg tablet once daily. Dosage may be adjusted based on individual response and tolerability, up to a maximum of 80 mg + 10 mg daily.
Elderly
No specific dose adjustment is generally required, but caution should be exercised due to potential age-related decrease in renal function.
Renal_impairment
No dose adjustment is necessary for mild to moderate renal impairment. For severe impairment, closer monitoring is recommended.
How to Take
Take orally, with or without food, at the same time each day.
Mechanism of Action
Telmisartan blocks the action of angiotensin II, a substance in the body that constricts blood vessels, leading to lower blood pressure. Amlodipine relaxes blood vessels and improves blood flow by blocking calcium from entering the muscle cells of the heart and blood vessels.
Pharmacokinetics
Onset
Telmisartan: gradual, full effect in 4-8 weeks. Amlodipine: 6-12 hours.
Excretion
Telmisartan: mainly excreted unchanged in feces. Amlodipine: primarily excreted via urine as inactive metabolites.
Half life
Telmisartan: approximately 24 hours. Amlodipine: 30-50 hours.
Absorption
Telmisartan is well absorbed, about 42-58%, with peak plasma concentrations occurring within 0.5-1 hour. Amlodipine is well absorbed, with peak concentrations reached in 6-12 hours, and bioavailability of 64-90%.
Metabolism
Telmisartan: minimally metabolized, mainly by glucuronidation. Amlodipine: extensively metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to telmisartan, amlodipine, or any component of the formulation
- Pregnancy (second and third trimesters)
- Severe hepatic impairment
- Biliary obstructive disorders
Drug Interactions
NSAIDs
Reduced antihypertensive effect and risk of renal impairment
Digoxin
Increased levels of Digoxin
Lithium
Increased serum lithium concentrations and toxicity
Simvastatin
Co-administration with Amlodipine requires dose adjustment of Simvastatin
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include marked hypotension and tachycardia (or bradycardia). Treatment is symptomatic and supportive. Amlodipine overdose may require gastric lavage and activated charcoal. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Contraindicated in the 2nd and 3rd trimesters of pregnancy. Advise women of childbearing potential about the risk of exposure. Not recommended during breastfeeding due to potential risk to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available, patents expired for components
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Telmisartan and Amlodipine combination in managing hypertension and reducing cardiovascular risk.
Lab Monitoring
- Blood pressure monitoring
- Renal function (serum creatinine, BUN)
- Serum electrolytes (especially potassium)
Doctor Notes
- Monitor blood pressure and renal function regularly.
- Educate patients on symptoms of angioedema.
- Caution in patients with severe aortic stenosis or hypertrophic obstructive cardiomyopathy.
Patient Guidelines
- Take medication regularly as prescribed.
- Do not stop taking the medication abruptly.
- Report any unusual side effects to your doctor.
- Avoid sudden changes in posture to prevent dizziness.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid smoking and limit alcohol intake.
- Monitor blood pressure regularly at home.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.